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Details on Person PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol]

Class:Id	Complex:6811477
_displayName	PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol]
_timestamp	2016-02-19 18:12:45
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6811512] Orlic-Milacic, Marija, 2015-11-19
hasComponent	[EntityWithAccessionedSequence:6811515] IER3 [cytosol] [Homo sapiens] [DefinedSet:1268261] p-T,Y MAPK dimers [cytosol] [Homo sapiens] [Complex:6811526] PP2A-B56-beta,gamma [cytosol] [Homo sapiens] [CandidateSet:165990] PP2A-subunit A [cytosol] [Homo sapiens] [CandidateSet:165977] PP2A-catalytic subunit C [cytosol] [Homo sapiens] [DefinedSet:6811516] PPP2R5B,PPP2R5C [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:199957] B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK [LiteratureReference:6811494] Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity
name	PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers PP2A:IEX1:p-T,Y-ERKs
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8859127] R-HSA-6811477.1
(input)	[Reaction:6811454] MAPKs phosphorylate PP2A [Homo sapiens]
(output)	[Reaction:6811472] IER3 recruits MAPKs to PP2A-B56-beta,gamma [Homo sapiens]
(physicalEntity)	[CatalystActivity:6811498] protein serine/threonine kinase activity of PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol]
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No pathways have been reviewed or authored by PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (6811477)