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Details on Person MAPKs phosphorylate PP2A

Class:Id	Reaction:6811454
_displayName	MAPKs phosphorylate PP2A
_doRelease	TRUE
_timestamp	2016-02-19 18:20:00
authored	[InstanceEdit:8850549] Orlic-Milacic, Marija, 2015-12-21
catalystActivity	[CatalystActivity:6811498] protein serine/threonine kinase activity of PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6811512] Orlic-Milacic, Marija, 2015-11-19
edited	[InstanceEdit:8850549] Orlic-Milacic, Marija, 2015-12-21
input	[Complex:6811477] PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:199957] B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK [LiteratureReference:6811494] Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity
modified	[InstanceEdit:6811557] Orlic-Milacic, Marija, 2015-11-19 [InstanceEdit:8856766] Orlic-Milacic, Marija, 2016-02-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAPKs phosphorylate PP2A
output	[SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:6811515] IER3 [cytosol] [Homo sapiens] [DefinedSet:1268261] p-T,Y MAPK dimers [cytosol] [Homo sapiens] [DefinedSet:6811475] p-S368-PPP2R5B,p-S337-PPP2R5C [cytosol] [Homo sapiens] [Complex:6811485] PP2A-A:PP2A-C [cytosol] [Homo sapiens]
precedingEvent	[Reaction:6811472] IER3 recruits MAPKs to PP2A-B56-beta,gamma [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8856765] Porteu, Fran�oise, 2016-02-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861006] R-HSA-6811454.2
summation	[Summation:6811520] Activated MAPK1 (ERK2) or MAPK3 (ERK1), recruited to the PP2...
(hasEvent)	[Pathway:6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [Homo sapiens]
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No pathways have been reviewed or authored by MAPKs phosphorylate PP2A (6811454)