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Details on Person RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange

Class:Id	Reaction:6811429
_displayName	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange
_doRelease	TRUE
_timestamp	2016-02-19 18:20:01
authored	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
catalystActivity	[CatalystActivity:6811410] guanyl-nucleotide exchange factor activity of RAB6:GDP:RIC1:RGP1 [trans-Golgi network membrane]
compartment	[Compartment:263163] trans-Golgi network membrane
created	[InstanceEdit:6811430] Rothfels, Karen, 2015-11-19
edited	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
input	[Complex:6811355] RAB6:GDP:RIC1:RGP1 [trans-Golgi network membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6811245] Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase [LiteratureReference:6811196] An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes [LiteratureReference:6811248] Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p [LiteratureReference:6811204] Characterization of the human GARP (Golgi associated retrograde protein) complex [LiteratureReference:6811243] Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes [LiteratureReference:6811214] Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network [LiteratureReference:6811268] Transport according to GARP: receiving retrograde cargo at the trans-Golgi network
modified	[InstanceEdit:8856706] Rothfels, Karen, 2016-02-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange
output	[Complex:6811353] RAB6:GTP:RIC1:RGP1 [trans-Golgi network membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:6811428] RIC1:RGP1 recruits RAB6:GDP to the TGN [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855182] Gillespie, Marc E, 2016-02-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861009] R-HSA-6811429.2
summation	[Summation:6811294] The RIC1:RGP1 complex stimulates nucleotide exchange on tran...
(hasEvent)	[Pathway:6811440] Retrograde transport at the Trans-Golgi-Network [Homo sapiens]
(precedingEvent)	[Reaction:6811431] RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles [Homo sapiens]
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No pathways have been reviewed or authored by RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (6811429)