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Details on Person RIC1:RGP1 recruits RAB6:GDP to the TGN

Class:Id	Reaction:6811428
_displayName	RIC1:RGP1 recruits RAB6:GDP to the TGN
_doRelease	TRUE
_timestamp	2016-02-19 18:20:01
authored	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
compartment	[Compartment:263163] trans-Golgi network membrane
created	[InstanceEdit:6811430] Rothfels, Karen, 2015-11-19
edited	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
input	[Complex:6811310] RAB6:GDP [cytosol] [Homo sapiens] [Complex:6811347] RIC1:RGP1 [trans-Golgi network membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6811225] Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi [LiteratureReference:6811235] RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex [LiteratureReference:6805380] Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP [LiteratureReference:6811233] Multiple aspects of Rab protein action in the secretory pathway: focus on Rab3 and Rab6 [LiteratureReference:6811193] A two-tier Golgi-based control of organelle size underpins the functional plasticity of endothelial cells [LiteratureReference:6811205] Cisternal rab proteins regulate Golgi apparatus redistribution in response to hypotonic stress [LiteratureReference:6811219] GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum [LiteratureReference:6811238] Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages [LiteratureReference:6811216] Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number [LiteratureReference:6811242] Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A' [LiteratureReference:6811245] Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase [LiteratureReference:6811248] Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p [LiteratureReference:6811196] An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes
modified	[InstanceEdit:8856707] Rothfels, Karen, 2016-02-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RIC1:RGP1 recruits RAB6:GDP to the TGN
output	[Complex:6811355] RAB6:GDP:RIC1:RGP1 [trans-Golgi network membrane] [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855182] Gillespie, Marc E, 2016-02-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861010] R-HSA-6811428.2
summation	[Summation:6811288] RAB proteins are required for the RINT-1/ZW10 and COG-depend...
(hasEvent)	[Pathway:6811440] Retrograde transport at the Trans-Golgi-Network [Homo sapiens]
(precedingEvent)	[Reaction:6811429] RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange [Homo sapiens]
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