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Details on Person Transglutaminase-1 (TGM1) and involucrin (IVL) are expressed...

Class:IdSummation:6810915
_displayNameTransglutaminase-1 (TGM1) and involucrin (IVL) are expressed...
_timestamp2015-12-03 17:26:54
created[InstanceEdit:6810925] Jupe, Steve, 2015-11-19
literatureReference[LiteratureReference:6811548] The transglutaminase 1 enzyme is variably acylated by myristate and palmitate during differentiation in epidermal keratinocytes
[LiteratureReference:6811531] Bricks and mortar of the epidermal barrier
[LiteratureReference:6810918] Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope
[LiteratureReference:6811540] Involucrin cross-linking by transglutaminase 1. Binding to membranes directs residue specificity
[LiteratureReference:6814196] Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro
modified[InstanceEdit:6810942] Jupe, Steve, 2015-11-19
[InstanceEdit:6811543] Jupe, Steve, 2015-11-19
[InstanceEdit:6814182] Jupe, Steve, 2015-11-25
[InstanceEdit:8847957] Jupe, Steve, 2015-12-03
textTransglutaminase-1 (TGM1) and involucrin (IVL) are expressed shortly after envoplakin and periplakin. TGM1 associates with the plasma membrane via C14-16 fatty-acid adducts on its C-terminus (Steinert et al. 1996). IVL deposition precedes that of most other cornified envelope proteins (Nemes & Steinert 1999). It can bind the plasma membrane in a calcium and phosphatidyl-serine dependent manner, where it becomes a substrate for membrane-bound TGM1 and TGM5 (Nemes et al. 1999, Candi et al. 2001).
(summation)[Reaction:6810899] TGM1 and involucrin bind the plasma membrane [Homo sapiens]
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