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Details on Person PI(4,5)P2 is dephosphorylated to PI5P by TMEM55A or TMEM55B at the endosome membrane

Class:Id	Reaction:6810391
_displayName	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55A or TMEM55B at the endosome membrane
_doRelease	FALSE
_timestamp	2025-08-29 20:01:16
catalystActivity	[CatalystActivity:6810390] phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity of TMEM55A,TMEM55B [late endosome membrane]
compartment	[Compartment:172574] late endosome membrane
created	[InstanceEdit:6810403] Orlic-Milacic, Marija, 2015-11-16
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:6810404] PI(4,5)P2 [late endosome membrane]
internalReviewed	[InstanceEdit:8979318] D'Eustachio, Peter, 2017-02-24
isChimeric	FALSE
literatureReference	[LiteratureReference:6810393] The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases
modified	[InstanceEdit:6812817] Orlic-Milacic, Marija, 2015-11-20 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9965548] Orlic-Milacic, Marija, 2025-08-29
name	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55A or TMEM55B at the endosome membrane
output	[SimpleEntity:29372] Pi [cytosol] [SimpleEntity:1806212] PI5P [late endosome membrane]
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8895050] R-HSA-6810391.1
summation	[Summation:6810396] Type I (TMEM55B) or type II (TMEM55A) phosphatidylinositol-4...
(hasEvent)	[Pathway:1660517] Synthesis of PIPs at the late endosome membrane [Homo sapiens] [Pathway:6811554] Regulation of PI5P Levels [Homo sapiens]
(precedingEvent)	[Reaction:6811470] TIAM1 binds PI5P [Homo sapiens]
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No pathways have been reviewed or authored by PI(4,5)P2 is dephosphorylated to PI5P by TMEM55A or TMEM55B at the endosome membrane (6810391)