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Details on Person Loricrin (LOR) is the main component of the epidermal cornif...

Class:Id	Summation:6810367
_displayName	Loricrin (LOR) is the main component of the epidermal cornif...
_timestamp	2015-11-27 16:53:16
created	[InstanceEdit:6810362] Jupe, Steve, 2015-11-16
literatureReference	[LiteratureReference:6810363] Assembly of the epidermal cornified cell envelope [LiteratureReference:6810349] The cornified envelope: a model of cell death in the skin [LiteratureReference:6810346] Biochemical evidence that small proline-rich proteins and trichohyalin function in epithelia by modulation of the biomechanical properties of their cornified cell envelopes [LiteratureReference:6810352] Sequence and expression patterns of mouse SPR1: Correlation of expression with epithelial function [LiteratureReference:6810575] The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope [LiteratureReference:6810851] Structure, function, and dynamics of keratin intermediate filaments [LiteratureReference:6810833] Transglutaminases: crosslinking enzymes with pleiotropic functions [LiteratureReference:6810844] The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin [LiteratureReference:6810860] Biochemical, structural, and transglutaminase substrate properties of human loricrin, the major epidermal cornified cell envelope protein [LiteratureReference:6810847] Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin [LiteratureReference:6810852] Structural and transglutaminase substrate properties of the small proline-rich 2 family of cornified cell envelope proteins [LiteratureReference:6810866] Transglutaminase crosslinking and structural studies of the human small proline rich 3 protein
modified	[InstanceEdit:6810576] Jupe, Steve, 2015-11-18 [InstanceEdit:6810835] Jupe, Steve, 2015-11-19 [InstanceEdit:6814377] Jupe, Steve, 2015-11-26 [InstanceEdit:6814704] Jupe, Steve, 2015-11-27 [InstanceEdit:6814761] Jupe, Steve, 2015-11-27
text	Loricrin (LOR) is the main component of the epidermal cornified envelope (CE). Comprising 70–85% of the total protein mass of the CE (Steinert & Marekov 1995), it is thought to function as the main reinforcement protein. LOR is extensively crosslinked through isopeptide bonds but also crosslinked to small proline-rich proteins (SPRs), which may function as bridging proteins between LOR molecules (Candi et al. 2005). Loricrin can also form crosslinks with keratin and filaggrin (Steinert 1993). Crosslinking in the cornified envelope involves the formation of very stable isopeptide bonds that are catalysed by transglutaminases TG1, TG3 and TG5 (Lorand & Graham 2003). The type-II keratin chains (K1, K2e and K5) are crosslinked by TGs at a specific Lys residue that is located in a conserved region of the V1 subdomain of the head domain (Steinert & Marekov 1995). Involucrin can be crosslinked by TG1, which preferentially crosslinks residues Gln495 and Gln496 (Simon & Green 1998). In vitro, LOR is a substrate for TG1, TG2, TG3 and TG5 (Candi et al. 1995). In the epidermis, TG1, TG5 and TG3 are believed to crosslink LOR sequentially; an initial attachment by TG1 and TG5 forms interchain crosslinks followed by a compaction process that involves TG3 (Candi et al. 2005). SPRs are also TG substrates, particularly TG3 (Candi et al. 1999, Tarcsa et al. 1998, Steinert et al. 1999).
(summation)	[Reaction:6810350] Crosslinking of cornified envelope proteins [Homo sapiens]
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