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Details on Person Fillagrin and keratin intermediate filaments polymerize forming a network

Class:Id	Polymerisation:6810357
_displayName	Fillagrin and keratin intermediate filaments polymerize forming a network
_doRelease	TRUE
_timestamp	2023-02-17 20:48:55
authored	[InstanceEdit:8863769] Jupe, Steve, 2016-03-10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6810362] Jupe, Steve, 2015-11-16
edited	[InstanceEdit:8934545] Jupe, Steve, 2016-08-10
input	[Complex:8942225] FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6810575] The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope
modified	[InstanceEdit:6810835] Jupe, Steve, 2015-11-19 [InstanceEdit:6814377] Jupe, Steve, 2015-11-26 [InstanceEdit:6814704] Jupe, Steve, 2015-11-27 [InstanceEdit:6814761] Jupe, Steve, 2015-11-27 [InstanceEdit:8848045] Jupe, Steve, 2015-12-04 [InstanceEdit:8848525] Jupe, Steve, 2015-12-09 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933244] Jupe, Steve, 2016-08-04 [InstanceEdit:8934483] Jupe, Steve, 2016-08-09 [InstanceEdit:8934545] Jupe, Steve, 2016-08-10 [InstanceEdit:8934782] Jupe, Steve, 2016-08-12 [InstanceEdit:8942227] Jupe, Steve, 2016-10-11 [InstanceEdit:9828802] Orlic-Milacic, Marija, 2023-02-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Fillagrin and keratin intermediate filaments polymerize forming a network
output	[Polymer:6814323] FLG-Keratin filament network [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8942224] Filaggrin binds Keratin tonofilament:Desmosome [Homo sapiens] [Reaction:8849797] Membrane proteases cleave Profilaggrin producing Filaggrin [Homo sapiens] [Reaction:8934819] Cytoplasmic proteases cleave Profilaggrin producing Filaggrin [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8934809] Blumenberg, Miroslav, 2016-08-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8882709] R-HSA-6810357.4
summation	[Summation:6810366] During cornification a network of keratin intermediate filam...
(hasEvent)	[Pathway:6809371] Formation of the cornified envelope [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:6811539] Reinforcement of the Cornified Envelope [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782219] Update Tracker - [Polymerisation:6810357] Fillagrin and keratin intermediate filaments polymerise forming a network - v59:[add_removeInput, modifyText]
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