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Details on Person During activation of HOXB1 by retinoic acid in human embryon...
| Class:Id | Summation:6810156 |
|---|---|
| _displayName | During activation of HOXB1 by retinoic acid in human embryon... |
| _timestamp | 2015-11-15 08:29:55 |
| created | [InstanceEdit:6810152] May, Bruce, 2015-11-15 |
| text | During activation of HOXB1 by retinoic acid in human embryonal carcinoma cells, methylation at lysine-27 of histone H3 (H3K27me3) is lost and methylation at lysine-4 (H3K4me3) is gained (Lan et al. 2007, Lee et al. 2007). The histone demethylase KDM6A (UTX) binds HOXB2 chromatin and may demethylate H3K27me3 (Lee et al. 2007). Other factors may also participate in demethylation. Loss of H3K27me3 is associated with loss of polycomb repressive complex 2 (PRC2) (Lan et al. 2007, Lee et al. 2007). KDM6A forms complexes with the histone methyltransferases KMT2C,D (MLL2,3) which may participate in methylating H3K4 (Lee et al. 2007). The activation of HOXB1 chromatin may be produced by euchromatin spreading from distant 3' retinoic acid response elements. |
| (summation) | [BlackBoxEvent:6810159] HOXB2 chromatin is activated [Homo sapiens] |
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No pathways have been reviewed or authored by During activation of HOXB1 by retinoic acid in human embryon... (6810156)
