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Details on Person SBF1 binds MTMR2

Class:Id	Reaction:6809764
_displayName	SBF1 binds MTMR2
_doRelease	TRUE
_timestamp	2025-08-12 22:18:03
authored	[InstanceEdit:6809880] Orlic-Milacic, Marija, 2015-11-13
catalystActivity	[CatalystActivity:9949585] protein-membrane adaptor activity of SBF1 [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9949587] protein-membrane adaptor activity of SBF1 [endoplasmic reticulum membrane] Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:6809751] Orlic-Milacic, Marija, 2015-11-12
edited	[InstanceEdit:8959448] Orlic-Milacic, Marija, 2017-01-25
input	[EntityWithAccessionedSequence:1604662] MTMR2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6809747] SBF1 [endoplasmic reticulum membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9949595] D'Eustachio, Peter, 2025-05-22
isChimeric	FALSE
literatureReference	[LiteratureReference:6809762] Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module [LiteratureReference:6809750] Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase [LiteratureReference:6809759] SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8959445] Orlic-Milacic, Marija, 2017-01-25 [InstanceEdit:8959447] Orlic-Milacic, Marija, 2017-01-25 [InstanceEdit:8959448] Orlic-Milacic, Marija, 2017-01-25 [InstanceEdit:8959449] Orlic-Milacic, Marija, 2017-01-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9949589] D'Eustachio, Peter, 2025-05-22 [InstanceEdit:9949594] D'Eustachio, Peter, 2025-05-22 [InstanceEdit:9962971] D'Eustachio, Peter, 2025-08-12
name	SBF1 binds MTMR2
output	[Complex:6809761] MTMR2:SBF1 [endoplasmic reticulum membrane] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2017-03-27
reviewed	[InstanceEdit:8959443] Rush, Mark G, 2017-01-10 [InstanceEdit:9962972] Hill, David P, 2025-08-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8912538] R-HSA-6809764.4
structureModified	[InstanceEdit:9949589] D'Eustachio, Peter, 2025-05-22
summation	[Summation:6809756] MTMR2 forms a heterodimer with SBF1 (MTMR5), an enzymaticall...
(hasEvent)	[Pathway:1483248] Synthesis of PIPs at the ER membrane [Homo sapiens] [Pathway:8874961] Myotubularins synthesize PIPs at the ER membrane [Homo sapiens]
(precedingEvent)	[Reaction:6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 [Homo sapiens] [Reaction:6809778] PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9953659] Update Tracker - [Reaction:6809764] SBF1 binds MTMR2 - v93:[removeCatalystActivity]
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