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Details on Person NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT

Class:Id	Reaction:6809354
_displayName	NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT
_doRelease	TRUE
_timestamp	2024-08-02 16:00:40
authored	[InstanceEdit:6809351] Jassal, Bijay, 2015-11-11
catalystActivity	[CatalystActivity:6809361] coenzyme A diphosphatase activity of NUDT7 [peroxisomal matrix]
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:6809351] Jassal, Bijay, 2015-11-11
crossReference	[DatabaseIdentifier:9914145] RHEA:64989
edited	[InstanceEdit:6809351] Jassal, Bijay, 2015-11-11
inferredFrom	[Reaction:6810452] Nudt7 hydrolyses CoA-SH to 3',5'-ADP and PPANT [Mus musculus]
input	[SimpleEntity:193514] CoA-SH [peroxisomal matrix] [SimpleEntity:141343] H2O [peroxisomal matrix]
internalReviewed	[InstanceEdit:9914192] D'Eustachio, Peter, 2024-06-21 [InstanceEdit:9914195] D'Eustachio, Peter, 2024-06-21
isChimeric	FALSE
literatureReference	[LiteratureReference:6809359] The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives [LiteratureReference:6809355] The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis
modified	[InstanceEdit:6809409] Jassal, Bijay, 2015-11-11 [InstanceEdit:6810455] Jassal, Bijay, 2015-11-17 [InstanceEdit:6810456] Jassal, Bijay, 2015-11-17 [InstanceEdit:8847948] Jassal, Bijay, 2015-12-03 [InstanceEdit:8851786] Jassal, Bijay, 2016-01-11 [InstanceEdit:9695863] Jassal, Bijay, 2020-07-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9914142] D'Eustachio, Peter, 2024-06-20 [InstanceEdit:9914193] D'Eustachio, Peter, 2024-06-21 [InstanceEdit:9914196] D'Eustachio, Peter, 2024-06-21 [InstanceEdit:9917351] D'Eustachio, Peter, 2024-08-02
name	NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT CoA + H2O => (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
output	[SimpleEntity:6809358] PPANT [peroxisomal matrix] [SimpleEntity:9641154] PAP [peroxisomal matrix] [SimpleEntity:193465] H+ [peroxisomal matrix] [SimpleEntity:193465] H+ [peroxisomal matrix]
precedingEvent	[Reaction:390304] acetyl-CoA + H2O => acetate + CoASH + H+ [Homo sapiens] [Reaction:390250] 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA [Homo sapiens] [BlackBoxEvent:390276] Conversion of 4,8,12-trimethyltridecanoyl-CoA to 4,8-dimethylnonanoyl-CoA [Homo sapiens] [BlackBoxEvent:390302] Beta-oxidation of tetradecenoyl-CoA to octanoyl-CoA [Homo sapiens] [Reaction:390291] acetyl-CoA + carnitine => acetylcarnitine + CoASH [Homo sapiens] [Reaction:390250] 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA [Homo sapiens] [BlackBoxEvent:390276] Conversion of 4,8,12-trimethyltridecanoyl-CoA to 4,8-dimethylnonanoyl-CoA [Homo sapiens] [BlackBoxEvent:390302] Beta-oxidation of tetradecenoyl-CoA to octanoyl-CoA [Homo sapiens] [Reaction:390284] propionyl-CoA + carnitine => propionylcarnitine + CoASH [Homo sapiens] [Reaction:390224] 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA [Homo sapiens] [BlackBoxEvent:390276] Conversion of 4,8,12-trimethyltridecanoyl-CoA to 4,8-dimethylnonanoyl-CoA [Homo sapiens] [Reaction:390281] 4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH [Homo sapiens] [BlackBoxEvent:390276] Conversion of 4,8,12-trimethyltridecanoyl-CoA to 4,8-dimethylnonanoyl-CoA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860998] R-HSA-6809354.4
structureModified	[InstanceEdit:9914142] D'Eustachio, Peter, 2024-06-20
summation	[Summation:6810451] Coenzyme A (CoASH) is a necessary cofactor for the oxidation...
(hasEvent)	[Pathway:390918] Peroxisomal lipid metabolism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9919507] Update Tracker - [Reaction:6809354] NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT - v90:[add_removeOutput]
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