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Details on Person IL35 binds IL-12RB2:IL6ST receptor

Class:Id	BlackBoxEvent:6809140
_displayName	IL35 binds IL-12RB2:IL6ST receptor
_doRelease	TRUE
_timestamp	2017-04-16 01:47:55
authored	[InstanceEdit:6788465] Garapati, Phani Vijay, 2015-07-21
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:6809137] Garapati, Phani Vijay, 2015-11-09
edited	[InstanceEdit:6788465] Garapati, Phani Vijay, 2015-07-21
input	[Complex:622267] IL35 [extracellular region] [Homo sapiens] [Complex:8950039] IL12RB2:JAK2 [plasma membrane] [Homo sapiens] [Complex:1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:6809142] The composition and signaling of the IL-35 receptor are unconventional [LiteratureReference:449993] Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
modified	[InstanceEdit:6809156] Garapati, Phani Vijay, 2015-11-09 [InstanceEdit:8950688] Duenas, Corina, 2016-12-02 [InstanceEdit:8981125] Duenas, Corina, 2017-03-01 [InstanceEdit:8983517] Varusai, Thawfeek, 2017-03-24 [InstanceEdit:8983984] Varusai, Thawfeek, 2017-04-03 [InstanceEdit:8985450] Varusai, Thawfeek, 2017-04-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL35 binds IL-12RB2:IL6ST receptor Interleukin-35 binds Interleukin-35 receptor Interleukin-35 binds Interleukin-6 receptor beta:Interleukin 12 Receptor beta 2 complex
output	[Complex:6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST [Homo sapiens] [BlackBoxEvent:448627] Interleukin-35 translocates from the ER lumen to the extracellular region [Homo sapiens] [BlackBoxEvent:8950740] CANX dissociates from IL12A:EBI3 [Homo sapiens] [Reaction:8950063] IL12RB2 binds JAK2 [Homo sapiens] [BlackBoxEvent:9942734] TBX21 positively regulates expression of IL12RB2 [Homo sapiens]
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6809153] Narazaki, M, Tanaka, M, 2015-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812516] R-HSA-6809140.4
summation	[Summation:6809136] Interleukin-35 (IL35) is a heteromeric complex of Interleuki...
(hasEvent)	[Pathway:8984722] Interleukin-35 Signalling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8950405] JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781171] Update Tracker - [BlackBoxEvent:6809140] IL35 binds IL-12RB2:IL6ST receptor - v61:[modifyText] [_UpdateTracker:9781668] Update Tracker - [BlackBoxEvent:6809140] IL35 binds IL-12RB2:IL6ST receptor - v60:[add_removeInput, add_removeLiteratureReference, modifyText]
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