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Details on Person IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]

Class:Id	Complex:6809138
_displayName	IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]
_timestamp	2017-04-16 01:49:57
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6809137] Garapati, Phani Vijay, 2015-11-09
hasComponent	[Complex:622267] IL35 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:448418] EBI3 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:447212] IL12A [extracellular region] [Homo sapiens] [Complex:1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] [Homo sapiens] [CandidateSet:1067656] JAK1, JAK2, (TYK2) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:448453] IL6ST [plasma membrane] [Homo sapiens] [Complex:8950039] IL12RB2:JAK2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:447249] IL12RB2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:210620] JAK2 [cytosol] [Homo sapiens]
includedLocation	[Compartment:984] extracellular region
literatureReference	[LiteratureReference:8949808] Interleukin-35 induces regulatory B cells that suppress autoimmune disease
modified	[InstanceEdit:6809156] Garapati, Phani Vijay, 2015-11-09 [InstanceEdit:8950093] Duenas, Corina, 2016-12-02 [InstanceEdit:8985450] Varusai, Thawfeek, 2017-04-16
name	IL35:IL6ST:JAK1:IL12RB2:JAK2 IL35:IL12RB2:JAK2:gp130:JAK2
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812261] R-HSA-6809138.3
summation	[Summation:8950087] Interleukin-35(IL-35) ,a heterodimer composed by Interleukin...
(input)	[BlackBoxEvent:8950405] JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated [Homo sapiens]
(output)	[BlackBoxEvent:6809140] IL35 binds IL-12RB2:IL6ST receptor [Homo sapiens]
(physicalEntity)	[CatalystActivity:9006665] transmembrane receptor protein tyrosine kinase activity of IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]
(updatedInstance)	[_UpdateTracker:9896360] Update Tracker - [Complex:6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - v60:[addLiteratureReference, addSummation, add_removeHasComponent, modifyName, updateContainedComponent] [_UpdateTracker:9896916] Update Tracker - [Complex:6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - v61:[add_removeHasComponent, modifyName]
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No pathways have been reviewed or authored by IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (6809138)