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Details on Person ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG

Class:Id	Reaction:6808496
_displayName	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG
_doRelease	TRUE
_timestamp	2016-02-24 20:44:34
authored	[InstanceEdit:6808508] D'Eustachio, Peter, 2015-11-04
catalystActivity	[CatalystActivity:6808489] aldehyde dehydrogenase (NAD+) activity of ALDH1L1 tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643127] aldehyde dehydrogenase (NAD) activity of ALDH1L1 tetramer [cytosol] ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6808500] D'Eustachio, Peter, 2015-11-04
edited	[InstanceEdit:6808508] D'Eustachio, Peter, 2015-11-04
input	[SimpleEntity:111353] 10-formyl-THFPG [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6808497] ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase [LiteratureReference:6808494] Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase
modified	[InstanceEdit:6808508] D'Eustachio, Peter, 2015-11-04 [InstanceEdit:8847417] D'Eustachio, Peter, 2015-11-30 [InstanceEdit:8856621] D'Eustachio, Peter, 2016-02-11 [InstanceEdit:8862014] D'Eustachio, Peter, 2016-02-23 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG
output	[SimpleEntity:197969] THFPG [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:113528] CO2 [cytosol]
precedingEvent	[Reaction:200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate [Homo sapiens] [Reaction:200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ [Homo sapiens] [Reaction:200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG [Homo sapiens] [Reaction:197958] FPGS-2 transforms THF to THFPG [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8847416] Jassal, Bijay, 2015-11-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8862051] R-HSA-6808496.3
summation	[Summation:6808498] ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) ...
(hasEvent)	[Pathway:196757] Metabolism of folate and pterines [Homo sapiens]
(precedingEvent)	[Reaction:200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG [Homo sapiens]
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