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Details on Person UniProt:Q6T707 Scd4
| Class:Id | ReferenceGeneProduct:6807927 |
|---|---|
| _chainChangeLog | chain:1-353 added on Tue November 3 2015 |
| _displayName | UniProt:Q6T707 Scd4 |
| _timestamp | 2025-02-21 19:53:49 |
| chain | chain:1-353 |
| checksum | EEF07F95776A4E0D |
| comment | FUNCTION Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:12815040, PubMed:16443825). Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).CATALYTIC ACTIVITY octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2OCATALYTIC ACTIVITY hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2OCOFACTOR Expected to bind 2 Fe(2+) ions per subunit.SUBCELLULAR LOCATION Detected in heart, but not in brain, liver, skin or adipose tissue.INDUCTION Up-regulated by agonists that activate NR1H3. Up-regulated by a fat-free high-carbohydrate diet. Not down-regulated by a high-carbohydrate diet supplemented with unsaturated fatty acids. Down-regulated by leptin.DOMAIN The histidine box domains are involved in binding the catalytic metal ions.SIMILARITY Belongs to the fatty acid desaturase type 1 family. |
| created | [InstanceEdit:6807888] Weiser, JD |
| description | recommendedName: fullName evidence="6"Stearoyl-CoA desaturase 4 ecNumber evidence="4 5"1.14.19.1 alternativeName: fullName evidence="8"Acyl-CoA desaturase 4 alternativeName: fullName evidence="7"Delta(9)-desaturase 4 shortName evidence="7"Delta-9 desaturase 4 alternativeName: fullName evidence="8"Fatty acid desaturase 4 |
| geneName | Scd4 |
| identifier | Q6T707 |
| isSequenceChanged | FALSE |
| keyword | Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Iron Lipid biosynthesis Lipid metabolism Membrane Metal-binding Microsome Oxidoreductase Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Scd4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SCD4_MOUSE B9EIY5 |
| sequenceLength | 353 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9917965] Scd4 [endoplasmic reticulum membrane] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q6T707 Scd4 (6807927)
