Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person LDHAL6B reduces PYR to LACT

Class:Id	Reaction:6807826
_displayName	LDHAL6B reduces PYR to LACT
_doRelease	TRUE
_timestamp	2025-01-25 19:09:15
authored	[InstanceEdit:6809179] D'Eustachio, Peter, 2015-11-09
catalystActivity	[CatalystActivity:6807609] L-lactate dehydrogenase (NAD+) activity of LDHAL6B [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6807828] D'Eustachio, Peter, 2015-11-03
crossReference	[DatabaseIdentifier:9861798] RHEA:23447
edited	[InstanceEdit:6809179] D'Eustachio, Peter, 2015-11-09
goBiologicalProcess	[GO_BiologicalProcess:8716] pyruvate fermentation to lactate
input	[SimpleEntity:113557] PYR [mitochondrial matrix] [SimpleEntity:29362] NADH [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:6807610] Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs [LiteratureReference:6807619] Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis
modified	[InstanceEdit:6807829] D'Eustachio, Peter, 2015-11-03 [InstanceEdit:6808455] D'Eustachio, Peter, 2015-11-04 [InstanceEdit:6809180] D'Eustachio, Peter, 2015-11-09 [InstanceEdit:6809429] D'Eustachio, Peter, 2015-11-11 [InstanceEdit:9012031] Jassal, Bijay, 2017-07-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861803] Stephan, Ralf, 2024-02-21 [InstanceEdit:9862190] Stephan, Ralf, 2024-02-23 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24 [InstanceEdit:9936712] D'Eustachio, Peter, 2025-01-25
name	LDHAL6B reduces PYR to LACT
negativePrecedingEvent	[NegativePrecedingEvent:9908910] Futile Cycle: DLD dimer dehydrogenates dihydrolipoyl [NegativePrecedingEvent:9908918] Futile Cycle: ME2 tetramer decarboxylates MAL to PYR
output	[SimpleEntity:6807616] LACT [mitochondrial matrix] [SimpleEntity:113526] NAD+ [mitochondrial matrix]
precedingEvent	[Reaction:372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [Homo sapiens] [Reaction:71670] Pyruvate kinase dephosphorylates PEP to PYR [Homo sapiens] [Reaction:70510] LDH tetramer oxidises LACT to PYR [Homo sapiens] [Reaction:70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Homo sapiens] [Reaction:9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Homo sapiens] [Reaction:9012016] FAHD1 dimer hydrolyses OA to PYR [Homo sapiens] [Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:70501] PC carboxylates PYR to OA [Homo sapiens] [Reaction:9012349] ME3 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:70982] FH tetramer hydrates fumarate to L-malate [Homo sapiens]
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6809181] Jassal, Bijay, 2015-11-09 [InstanceEdit:9862191] Hill, David P, 2024-02-23
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:6809179] D'Eustachio, Peter, 2015-11-09
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812505] R-HSA-6807826.6
summation	[Summation:6807827] LDHAL6B (L-lactate dehydrogenase A-like 6B) catalyzes the re...
(hasEvent)	[Pathway:70268] Pyruvate metabolism [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9908911] Futile Cycle: LDHAL6B reduces PYR to LACT [NegativePrecedingEvent:9908921] Futile Cycle: LDHAL6B reduces PYR to LACT [Reaction:9861626] SIRT4 cleaves lipoyl from DLAT [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by LDHAL6B reduces PYR to LACT (6807826)