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Details on Person UniProt:P46587 SSA2
| Class:Id | ReferenceGeneProduct:6807567 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Wed November 4 2015;chain:2-645 added on Wed November 4 2015;initiator methionine:1 for 6807567 removed on Fri Nov 03 2023;initiator methionine: for 6807567 added on Fri Nov 03 2023;initiator methionine: for 6807567 removed on Fri Aug 15 2025;initiator methionine:1 for 6807567 added on Fri Aug 15 2025 |
| _displayName | UniProt:P46587 SSA2 |
| _timestamp | 2025-08-15 21:07:54 |
| chain | initiator methionine:1 chain:2-645 |
| checksum | 063BD314C9755686 |
| comment | FUNCTION Heat shock protein that may play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum.FUNCTION Acts as a highly immunodominant antigen (PubMed:15378761, PubMed:17051645, PubMed:8757872). Plays a role in the sensitivity to, and the import of candidacidal beta-defensin peptides (PubMed:16377704). HSP70/SSA1 and SSA2 bind histatin-5, a peptide from human saliva, and mediates its fungicidal activity (PubMed:12761219, PubMed:16720580, PubMed:17999963, PubMed:19006817, PubMed:9685398). SSA2 facilitates fungicidal activity of Hst 5 in binding and intracellular translocation, whereas HSP70/SSA1 appears to have a lesser functional role in Hst 5 toxicity (PubMed:16720580, PubMed:19006817).SUBUNIT Binds human histatin-5, an antifungal peptide from saliva.SUBCELLULAR LOCATION Expression is repressed by treatment with caspofungin.DOMAIN The regions defined by residues 128 to 135, 150 to 156 and 333 to 337 correspond to Hst 5-binding epitopes.DISRUPTION PHENOTYPE Does not affect cells growth and hyphal formation (PubMed:16720580). Leads to high resistance to the candidacidal activity of Hst 5 (PubMed:16377704, PubMed:16720580, PubMed:17999963).SIMILARITY Belongs to the heat shock protein 70 family. |
| created | [InstanceEdit:6807563] Shamovsky, Veronica, 2015-11-03 |
| description | recommendedName: fullName evidence="14"Heat shock protein SSA2 alternativeName: fullName evidence="14"SSA subfamily protein 2 |
| geneName | SSA2 SSA1 CAALFM_C104300CA CaO19.1065 CaO19.8667 |
| identifier | P46587 |
| isSequenceChanged | FALSE |
| keyword | Acetylation ATP-binding Cell wall Cytoplasm Nucleotide-binding Reference proteome Secreted Stress response |
| modified | [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SSA2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | HSP72_CANAL A0A1D8PD89 Q59VM8 |
| sequenceLength | 645 |
| species | [Species:104247] Candida albicans |
| (referenceEntity) | [EntityWithAccessionedSequence:6807592] SSA2 [plasma membrane] [Candida albicans] |
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No pathways have been reviewed or authored by UniProt:P46587 SSA2 (6807567)
