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Details on Person GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)

Class:Id	Reaction:6807214
_displayName	GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)
_doRelease	TRUE
_timestamp	2015-11-20 15:10:58
authored	[InstanceEdit:6809179] D'Eustachio, Peter, 2015-11-09
catalystActivity	[CatalystActivity:159812] gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:6807209] D'Eustachio, Peter, 2015-10-29
edited	[InstanceEdit:6809179] D'Eustachio, Peter, 2015-11-09
input	[EntityWithAccessionedSequence:6807212] BGLAP(24-100) [endoplasmic reticulum lumen] [Homo sapiens] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen]
literatureReference	[LiteratureReference:159755] The vitamin K-dependent carboxylase [LiteratureReference:6806818] GGCX and VKORC1 inhibit osteocalcin endocrine functions [LiteratureReference:159753] Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid [LiteratureReference:6807232] Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone [LiteratureReference:163831] Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate. [LiteratureReference:6807216] Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue [LiteratureReference:159750] Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo
modified	[InstanceEdit:6807221] D'Eustachio, Peter, 2015-10-29 [InstanceEdit:6807226] D'Eustachio, Peter, 2015-10-29 [InstanceEdit:6809429] D'Eustachio, Peter, 2015-11-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) pro-osteocalciin, uncarboxylated + 3 CO2 + 3 O2 + 3 vitamin K hydroquinone -> gamma-carboxylated pro-osteocalcin + 3 H2O + 3 vitamin K epoxide
output	[EntityWithAccessionedSequence:6807218] 3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen] [Homo sapiens] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen]
precedingEvent	[Reaction:159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) [Homo sapiens] [Reaction:159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) [Homo sapiens] [Reaction:159761] GGCX gamma-carboxylates F7(21-466) (pro-factor VII) [Homo sapiens] [Reaction:159819] GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) [Homo sapiens] [Reaction:159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) [Homo sapiens] [Reaction:159795] GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) [Homo sapiens] [Reaction:159752] GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) [Homo sapiens] [Reaction:163820] GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) [Homo sapiens] [Reaction:163810] GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) [Homo sapiens] [Reaction:6807214] GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) [Homo sapiens] [Reaction:6806674] UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) [Homo sapiens]
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6809181] Jassal, Bijay, 2015-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812503] R-HSA-6807214.2
summation	[Summation:6807213] GGCX (gamma glutamyl carboxylase) in the endoplasmic reticul...
(hasEvent)	[Pathway:159740] Gamma-carboxylation of protein precursors [Homo sapiens]
(precedingEvent)	[Reaction:159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) [Homo sapiens] [BlackBoxEvent:6807229] Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus [Homo sapiens]
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No pathways have been reviewed or authored by GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (6807214)