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Details on Person PTEN undergoes monoubiquitination

Class:Id	Reaction:6807106
_displayName	PTEN undergoes monoubiquitination
_doRelease	TRUE
_timestamp	2019-01-15 13:51:11
authored	[InstanceEdit:6807104] Orlic-Milacic, Marija, 2015-10-29
catalystActivity	[CatalystActivity:6807253] ubiquitin protein ligase activity of XIAP,NEDD4 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6807104] Orlic-Milacic, Marija, 2015-10-29
edited	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
input	[EntityWithAccessionedSequence:199420] PTEN [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5690089] Ubiquitination regulates PTEN nuclear import and tumor suppression [LiteratureReference:6807128] X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization
modified	[InstanceEdit:6807250] Orlic-Milacic, Marija, 2015-10-30 [InstanceEdit:6807254] Orlic-Milacic, Marija, 2015-10-30 [InstanceEdit:6807261] Orlic-Milacic, Marija, 2015-10-30 [InstanceEdit:6807300] Orlic-Milacic, Marija, 2015-10-30 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8942965] Orlic-Milacic, Marija, 2016-10-21 [InstanceEdit:8959458] Orlic-Milacic, Marija, 2017-01-25 [InstanceEdit:8985729] Orlic-Milacic, Marija, 2017-04-19 [InstanceEdit:9005631] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9006079] Orlic-Milacic, Marija, 2017-05-12 [InstanceEdit:9634778] Rothfels, Karen, 2019-01-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTEN undergoes monoubiquitination
output	[EntityWithAccessionedSequence:6807247] MonoUb-K13,K289-PTEN [cytosol] [Homo sapiens]
releaseDate	2017-06-12
reviewed	[InstanceEdit:8948085] Leslie, Nicholas, 2016-09-30 [InstanceEdit:8948084] Kriplani, Nisha, 2016-09-30 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11 [InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8896329] R-HSA-6807106.3
summation	[Summation:6807251] When present at low levels in the cell, the E3 ubiquitin lig...
(hasEvent)	[Pathway:8948747] Regulation of PTEN localization [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:6807105] Monoubiquitinated PTEN translocates to the nucleus [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778596] Update Tracker - [Reaction:6807106] PTEN undergoes monoubiquitination - v68:[add_removeInput]
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