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Details on Person DHCR7 reduces 7-dehydroCHOL to CHOL

Class:Id	Reaction:6807055
_displayName	DHCR7 reduces 7-dehydroCHOL to CHOL
_doRelease	TRUE
_timestamp	2025-04-11 19:40:13
authored	[InstanceEdit:6807519] D'Eustachio, Peter, 2015-11-02
catalystActivity	[CatalystActivity:196403] 7-dehydrocholesterol reductase activity of DHCR7 [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643633] 7-dehydrocholesterol reductase activity of DHCR7 [endoplasmic reticulum membrane] Molecular cloning and expression of the human delta7-sterol reductase
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:6807046] D'Eustachio, Peter, 2015-10-28
crossReference	[DatabaseIdentifier:9945224] RHEA:23986
edited	[InstanceEdit:6807519] D'Eustachio, Peter, 2015-11-02
input	[SimpleEntity:6807057] 7-dehydroCHOL [endoplasmic reticulum membrane] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6807051] Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol [LiteratureReference:6807060] Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways [LiteratureReference:196411] Molecular cloning and expression of the human delta7-sterol reductase
modified	[InstanceEdit:6807066] D'Eustachio, Peter, 2015-10-28 [InstanceEdit:6807518] D'Eustachio, Peter, 2015-11-02 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9945226] D'Eustachio, Peter, 2025-04-11
name	DHCR7 reduces 7-dehydroCHOL to CHOL 7-dehydrocholesterol + NADPH + H(+) => cholesterol + NADP(+)
output	[SimpleEntity:193384] CHOL [endoplasmic reticulum membrane] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:6807053] SC5D desaturates LTHSOL to 7-dehydroCHOL [Homo sapiens] [Reaction:6807052] EBP isomerizes ZYMSTNL to LTHSOL [Homo sapiens] [Reaction:76494] POR reduces CYP450:Fe3+ to CYP450:Fe2+ [Homo sapiens]
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6807520] Jassal, Bijay, 2015-11-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812501] R-HSA-6807055.4
summation	[Summation:6807049] DHCR7 (7-dehydrocholesterol reductase) associated with the e...
(hasEvent)	[Pathway:9969901] Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) [Homo sapiens]
(precedingEvent)	[Reaction:5250531] ARV1 transports CHOL from ER membrane to plasma membrane [Homo sapiens]
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