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Details on Person Diagram of Signaling by MET
| Class:Id | PathwayDiagram:6806937 |
|---|---|
| _displayName | Diagram of Signaling by MET |
| _timestamp | 2021-08-10 12:41:21 |
| created | [InstanceEdit:6806936] Orlic-Milacic, Marija, 2015-10-28 |
| height | 1592 |
| modified | [InstanceEdit:6806958] Orlic-Milacic, Marija, 2015-10-28 [InstanceEdit:6806982] Orlic-Milacic, Marija, 2015-10-28 [InstanceEdit:6807002] Orlic-Milacic, Marija, 2015-10-28 [InstanceEdit:6807005] Orlic-Milacic, Marija, 2015-10-28 [InstanceEdit:6807013] Orlic-Milacic, Marija, 2015-10-28 [InstanceEdit:6807028] Orlic-Milacic, Marija, 2015-10-28 [InstanceEdit:6807036] Orlic-Milacic, Marija, 2015-10-28 [InstanceEdit:8849224] Jassal, Bijay, 2015-12-14 [InstanceEdit:8851825] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851829] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851832] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851846] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851849] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851861] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851872] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851875] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851881] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851889] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851896] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851903] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851906] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851918] Orlic-Milacic, Marija, 2016-01-12 [InstanceEdit:8851922] Orlic-Milacic, Marija, 2016-01-12 [InstanceEdit:8851930] Orlic-Milacic, Marija, 2016-01-12 [InstanceEdit:8851946] Orlic-Milacic, Marija, 2016-01-12 [InstanceEdit:8851958] Orlic-Milacic, Marija, 2016-01-12 [InstanceEdit:8852034] Orlic-Milacic, Marija, 2016-01-12 [InstanceEdit:8852035] Orlic-Milacic, Marija, 2016-01-12 [InstanceEdit:8852039] Orlic-Milacic, Marija, 2016-01-12 [InstanceEdit:8866002] Orlic-Milacic, Marija, 2016-03-28 [InstanceEdit:8866337] Orlic-Milacic, Marija, 2016-03-30 [InstanceEdit:8866360] Orlic-Milacic, Marija, 2016-03-30 [InstanceEdit:8866381] Orlic-Milacic, Marija, 2016-03-31 [InstanceEdit:8874091] Orlic-Milacic, Marija, 2016-05-20 [InstanceEdit:8874095] Orlic-Milacic, Marija, 2016-05-20 [InstanceEdit:8874098] Orlic-Milacic, Marija, 2016-05-20 [InstanceEdit:8874571] Orlic-Milacic, Marija, 2016-05-24 [InstanceEdit:8874574] Orlic-Milacic, Marija, 2016-05-24 [InstanceEdit:8874578] Orlic-Milacic, Marija, 2016-05-24 [InstanceEdit:8874605] Orlic-Milacic, Marija, 2016-05-25 [InstanceEdit:8874614] Orlic-Milacic, Marija, 2016-05-25 [InstanceEdit:8874617] Orlic-Milacic, Marija, 2016-05-25 [InstanceEdit:8874701] Orlic-Milacic, Marija, 2016-05-25 [InstanceEdit:8875359] Orlic-Milacic, Marija, 2016-06-03 [InstanceEdit:8875376] Orlic-Milacic, Marija, 2016-06-03 [InstanceEdit:8875412] Orlic-Milacic, Marija, 2016-06-03 [InstanceEdit:8875438] Orlic-Milacic, Marija, 2016-06-05 [InstanceEdit:8875441] Orlic-Milacic, Marija, 2016-06-05 [InstanceEdit:8875446] Orlic-Milacic, Marija, 2016-06-05 [InstanceEdit:8875460] Orlic-Milacic, Marija, 2016-06-05 [InstanceEdit:8875484] Orlic-Milacic, Marija, 2016-06-06 [InstanceEdit:8875499] Orlic-Milacic, Marija, 2016-06-06 [InstanceEdit:8875507] Orlic-Milacic, Marija, 2016-06-06 [InstanceEdit:8875556] Orlic-Milacic, Marija, 2016-06-07 [InstanceEdit:8875562] Orlic-Milacic, Marija, 2016-06-07 [InstanceEdit:8875569] Orlic-Milacic, Marija, 2016-06-07 [InstanceEdit:8875572] Orlic-Milacic, Marija, 2016-06-07 [InstanceEdit:8875588] Orlic-Milacic, Marija, 2016-06-07 [InstanceEdit:8875592] Orlic-Milacic, Marija, 2016-06-07 [InstanceEdit:8875676] Orlic-Milacic, Marija, 2016-06-08 [InstanceEdit:8875753] Orlic-Milacic, Marija, 2016-06-08 [InstanceEdit:8875820] Orlic-Milacic, Marija, 2016-06-08 [InstanceEdit:8875943] Orlic-Milacic, Marija, 2016-06-09 [InstanceEdit:8875944] Orlic-Milacic, Marija, 2016-06-09 [InstanceEdit:8876359] Orlic-Milacic, Marija, 2016-06-13 [InstanceEdit:8876377] Orlic-Milacic, Marija, 2016-06-14 [InstanceEdit:8944136] Orlic-Milacic, Marija, 2016-11-03 [InstanceEdit:9029983] Orlic-Milacic, Marija, 2017-11-23 [InstanceEdit:9029984] Orlic-Milacic, Marija, 2017-11-23 [InstanceEdit:9029985] Orlic-Milacic, Marija, 2017-11-23 [InstanceEdit:9634811] Rothfels, Karen, 2019-01-15 [InstanceEdit:9644460] Matthews, Lisa, 2019-04-14 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9734138] Orlic-Milacic, Marija, 2021-06-15 [InstanceEdit:9735980] Orlic-Milacic, Marija, 2021-07-06 [InstanceEdit:9736003] Orlic-Milacic, Marija, 2021-07-06 [InstanceEdit:9736289] Orlic-Milacic, Marija, 2021-07-06 [InstanceEdit:9736295] Orlic-Milacic, Marija, 2021-07-06 [InstanceEdit:9750149] Orlic-Milacic, Marija, 2021-08-10 [InstanceEdit:9750150] Orlic-Milacic, Marija, 2021-08-10 |
| representedPathway | [Pathway:6806834] Signaling by MET [Homo sapiens] |
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<org.gk.render.RenderableReaction id="24" reactomeId="6800200" points="107 139, 139 149, 197 162" position="139 149" lineWidth="1.0"> <Inputs> <Input id="25" points="75 131" /> <Input id="26" points="80 165" /> </Inputs> <Outputs> <Output id="27" /> </Outputs> <Catalysts> <Catalyst id="145" points="139 210" /> </Catalysts> <Inhibitors> <Inhibitor id="16" points="95 71" /> </Inhibitors> <Properties> <displayName>HPN heterodimer cleaves pro-HGF to form HGF dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="29" reactomeId="6800299" points="112 116, 214 114, 234 158" position="214 114" lineWidth="1.0"> <Inputs> <Input id="25" points="86 116" /> <Input id="26" points="77 165" /> </Inputs> <Outputs> <Output id="27" /> </Outputs> <Catalysts> <Catalyst id="31" points="269 67" /> </Catalysts> <Inhibitors> <Inhibitor id="20" points="190 84" /> </Inhibitors> <Properties> <displayName>HGFAC cleaves pro-HGF to form HGF dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="32" reactomeId="6800298" points="290 209, 318 209, 352 214" position="318 209" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="33" points="274 218" /> <Input id="27" points="254 186" /> </Inputs> <Outputs> <Output id="34" /> </Outputs> <Inhibitors> <Inhibitor id="913" points="469 207, 388 176" /> </Inhibitors> <Properties> <displayName>HGF dimer binds MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="59" reactomeId="6806957" points="392 245, 388 279, 388 305" position="388 279" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="34" stoichiometry="2" /> </Inputs> <Outputs> <Output id="60" /> </Outputs> <Properties> <displayName>MET receptor dimerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="82" reactomeId="6806974" points="480 327, 527 329, 548 329" position="527 329" lineWidth="1.0"> <Inputs> <Input id="83" stoichiometry="8" points="468 370" /> <Input id="60" points="426 328" /> </Inputs> <Outputs> <Output id="887" stoichiometry="8" points="556 376" /> <Output id="84" points="602 316" /> </Outputs> <Catalysts> <Catalyst id="60" points="426 319, 479 304" /> </Catalysts> <Inhibitors> <Inhibitor id="940" points="522 296" /> </Inhibitors> <Properties> <displayName>MET dimers autophosphorylate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="118" reactomeId="6807008" points="782 290, 823 283, 874 285" position="823 283" lineWidth="1.0"> <Inputs> <Input id="84" points="753 291" /> <Input id="119" stoichiometry="2" points="768 350" /> </Inputs> <Outputs> <Output id="120" stoichiometry="2" points="899 353" /> <Output id="121" points="926 279" /> </Outputs> <Catalysts> <Catalyst id="122" points="824 315" /> </Catalysts> <Properties> <displayName>PTPRJ dephosphorylates MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="141" reactomeId="6807027" points="768 416, 827 413, 887 418" position="827 413" lineWidth="1.0"> <Inputs> <Input id="84" points="678 316" /> <Input id="119" stoichiometry="4" points="765 383" /> </Inputs> <Outputs> <Output id="120" stoichiometry="4" points="899 385" /> <Output id="143" points="977 345" /> </Outputs> <Catalysts> <Catalyst id="144" points="828 444" /> </Catalysts> <Properties> <displayName>PTPN1 and PTPN2 dephosphorylate MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="152" reactomeId="8851804" points="892 521, 956 518, 1068 514" position="956 518" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="84" points="674 316, 789 501" /> <Input id="153" points="884 544" /> </Inputs> <Outputs> <Output id="154" /> </Outputs> <Inhibitors> <Inhibitor id="193" points="1151 264" /> </Inhibitors> <Properties> <displayName>Activated MET recruits GRB2-1:SOS1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="168" reactomeId="8851827" points="1124 606, 1154 639, 1125 672" position="1154 639" lineWidth="1.0"> <Inputs> <Input id="169" points="1122 590" /> <Input id="170" points="1076 604" /> </Inputs> <Outputs> <Output id="172" points="1080 674" /> <Output id="171" points="1121 717" /> </Outputs> <Catalysts> <Catalyst id="154" points="1163 537, 1211 579" /> </Catalysts> <Properties> <displayName>RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="190" reactomeId="8851842" points="684 249, 718 238, 1091 242" position="718 238" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="191" points="640 244" /> <Input id="84" points="671 273" /> </Inputs> <Outputs> <Output id="193" /> </Outputs> <Properties> <displayName>MUC20 binds MET and inhibits GRB2 binding</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="208" reactomeId="8851859" points="795 653, 979 762, 1074 776" position="979 762" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="84" points="669 316" /> <Input id="209" points="850 655" /> <Input id="210" points="836 634" /> </Inputs> <Outputs> <Output id="211" /> </Outputs> <Inhibitors> <Inhibitor id="222" points="1066 822, 980 799" /> </Inhibitors> <Properties> <displayName>Activated MET binds RANBP9 and SOS1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="228" reactomeId="8851866" points="796 734, 964 828, 1049 835" position="964 828" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="229" points="830 733" /> <Input id="84" points="668 316" /> </Inputs> <Outputs> <Output id="222" /> </Outputs> <Properties> <displayName>MET binds RANBP10</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="241" reactomeId="8851877" points="1129 610, 1138 678, 1118 670" position="1138 678" lineWidth="1.0"> <Inputs> <Input id="169" points="1124 590" /> <Input id="170" points="1076 605" /> </Inputs> <Outputs> <Output id="171" points="1120 717" /> <Output id="172" points="1080 673" /> </Outputs> <Catalysts> <Catalyst id="211" points="1159 768, 1198 706" /> </Catalysts> <Properties> <displayName>RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="251" reactomeId="8851888" points="791 842, 956 872, 1099 883" position="956 872" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="252" points="821 822" /> <Input id="84" points="667 316" /> </Inputs> <Outputs> <Output id="253" /> </Outputs> <Properties> <displayName>MET binds SHC1-2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="262" reactomeId="8851890" points="1160 938, 1158 972, 1158 1000" position="1158 972" lineWidth="1.0"> <Inputs> <Input id="253" points="1168 910" /> <Input id="263" points="1097 937" /> </Inputs> <Outputs> <Output id="264" points="1153 1029" /> <Output id="265" points="1089 998" /> </Outputs> <Catalysts> <Catalyst id="253" points="1176 910, 1185 948" /> </Catalysts> <Properties> <displayName>MET phosphorylates SHC1-2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="272" reactomeId="8851900" points="1143 1104, 1243 1091, 1284 990" position="1243 1091" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="264" points="1148 1071" /> <Input id="153" points="845 568, 702 574, 729 1080" /> </Inputs> <Outputs> <Output id="273" /> </Outputs> <Properties> <displayName>SHC1-2 bound to MET recruits GRB2:SOS1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="278" reactomeId="8851899" points="1131 615, 1149 663, 1123 678" position="1149 663" lineWidth="1.0"> <Inputs> <Input id="169" points="1124 590" /> <Input id="170" points="1076 606" /> </Inputs> <Outputs> <Output id="171" points="1121 717" /> <Output id="172" points="1080 675" /> </Outputs> <Catalysts> <Catalyst id="273" points="1292 933, 1264 695" /> </Catalysts> <Properties> <displayName>RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="282" reactomeId="8851908" points="789 1130, 815 1133, 1127 1141" position="815 1133" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="84" points="663 316, 692 1118" /> <Input id="283" points="752 1169" /> </Inputs> <Outputs> <Output id="284" /> </Outputs> <Properties> <displayName>Activated MET binds GAB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="291" reactomeId="8851919" points="690 1253, 789 1241, 1100 1208" position="789 1241" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="84" points="662 316, 652 1247" /> <Input id="283" points="734 1197" /> <Input id="292" points="797 1208" /> </Inputs> <Outputs> <Output id="293" /> </Outputs> <Properties> <displayName>Activated MET binds GAB1 and GRB2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="294" reactomeId="8851933" points="1226 1346, 1224 1368, 1221 1390" position="1224 1368" lineWidth="1.0"> <Inputs> <Input id="295" points="1224 1315" /> <Input id="298" points="1191 1338" /> </Inputs> <Outputs> <Output id="299" points="1194 1381" /> <Output id="300" points="1240 1421" /> </Outputs> <Catalysts> <Catalyst id="295" points="1239 1315, 1264 1358" /> </Catalysts> <Properties> <displayName>MET phosphorylates GAB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="296" points="1234 1153, 1292 1167, 1243 1239" position="1292 1167" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="284" /> </Inputs> <Outputs> <Output id="295" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="297" points="1181 1223, 1198 1239" position="1189 1231" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="293" /> </Inputs> <Outputs> <Output id="295" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="313" reactomeId="8851954" points="978 1395, 960 1506, 908 1518" position="960 1506" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="314" points="948 1352" /> <Input id="300" points="1156 1433" /> </Inputs> <Outputs> <Output id="315" /> </Outputs> <Properties> <displayName>Phosphorylated GAB1 recruits PI3K to MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="320" reactomeId="8852019" points="849 1467, 816 1471, 774 1465" position="816 1471" lineWidth="1.0"> <Inputs> <Input id="321" points="869 1469" /> <Input id="322" points="876 1423" /> </Inputs> <Outputs> <Output id="323" points="745 1467" /> <Output id="324" points="735 1423" /> </Outputs> <Catalysts> <Catalyst id="315" points="816 1508" /> </Catalysts> <Properties> <displayName>MET bound PI3K generates PIP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="330" interactionType="Activate" points="682 1452, 635 1413" position="658 1432" lineWidth="2.0"> <Inputs> <Input id="323" /> </Inputs> <Outputs> <Output id="329" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="341" interactionType="Activate" points="1073 730, 986 730, 973 699" position="986 730" lineWidth="2.0"> <Inputs> <Input id="171" /> </Inputs> <Outputs> <Output id="339" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="358" reactomeId="8865994" points="1080 1467, 1090 1509" position="1080 1467" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="300" points="1156 1459" /> <Input id="359" points="1044 1447" /> </Inputs> <Outputs> <Output id="360" /> </Outputs> <Properties> <displayName>GAB1 binds PTPN11</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="374" reactomeId="8874079" points="557 536, 377 639, 179 640" position="377 639" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="376" points="550 570" /> <Input id="84" points="654 316" /> </Inputs> <Outputs> <Output id="377" /> </Outputs> <Activators> <Activator id="904" points="230 590, 296 592" /> </Activators> <Properties> <displayName>PTK2 binds activated MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="386" reactomeId="8874078" points="93 685, 89 717, 84 753" position="89 717" lineWidth="1.0"> <Inputs> <Input id="377" points="90 656" /> <Input id="387" points="105 685" /> </Inputs> <Outputs> <Output id="388" points="86 790" /> <Output id="389" points="114 757" /> </Outputs> <Catalysts> <Catalyst id="377" points="79 656, 52 684" /> </Catalysts> <Properties> <displayName>PTK2 autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="396" reactomeId="8874083" points="167 887, 132 914, 117 946" position="132 914" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="388" points="108 836" /> <Input id="397" points="127 882" /> </Inputs> <Outputs> <Output id="398" /> </Outputs> <Properties> <displayName>p-Y397-PTK2 binds SRC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="406" reactomeId="8874082" points="107 1034, 108 1059, 109 1079" position="108 1059" lineWidth="1.0"> <Inputs> <Input id="398" points="107 1002" /> <Input id="407" points="124 1034" /> </Inputs> <Outputs> <Output id="408" points="135 1079" /> <Output id="409" points="109 1102" /> </Outputs> <Catalysts> <Catalyst id="398" points="94 1002, 73 1042" /> </Catalysts> <Properties> <displayName>MET phosphorylates PTK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="424" reactomeId="8874080" points="107 1179, 107 1200, 109 1228" position="107 1200" lineWidth="1.0"> <Inputs> <Input id="425" stoichiometry="2" points="153 1182" /> <Input id="409" points="107 1162" /> </Inputs> <Outputs> <Output id="426" stoichiometry="2" points="150 1224" /> <Output id="427" points="106 1263" /> </Outputs> <Catalysts> <Catalyst id="409" points="85 1162, 57 1193" /> </Catalysts> <Properties> <displayName>SRC phosphorylates PTK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="436" reactomeId="8874685" points="1141 387, 1153 372, 1191 348" position="1153 372" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="437" points="1181 398" /> <Input id="888" points="1119 395" /> </Inputs> <Outputs> <Output id="891" /> </Outputs> <Properties> <displayName>CBL binds MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="452" reactomeId="8875183" points="1627 304, 1649 308, 1673 307" position="1649 308" lineWidth="1.0"> <Inputs> <Input id="899" points="1606 299" /> <Input id="906" points="1587 352" /> </Inputs> <Outputs> <Output id="902" /> </Outputs> <Catalysts> <Catalyst id="899" points="1606 276, 1628 271" /> </Catalysts> <Properties> <displayName>CBL monoubiquitinates activated MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="457" reactomeId="8875374" points="191 254, 197 274, 166 302" position="197 274" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="33" points="213 243" /> <Input id="458" points="173 258" /> </Inputs> <Outputs> <Output id="459" /> </Outputs> <Properties> <displayName>MET binds LRIG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="480" reactomeId="8875431" points="218 345, 251 359, 291 287" position="251 359" lineWidth="1.0"> <Inputs> <Input id="459" points="173 330" /> <Input id="908" points="192 362" /> </Inputs> <Outputs> <Output id="481" /> </Outputs> <Catalysts> <Catalyst id="482" points="210 413, 249 411" /> </Catalysts> <Properties> <displayName>LRIG1 undergoes ubiquitination</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="501" reactomeId="8875443" points="309 319, 262 300, 219 276" position="262 300" lineWidth="1.0"> <Inputs> <Input id="481" points="307 287" /> <Input id="502" points="343 409" /> </Inputs> <Outputs> <Output id="459" points="173 308" /> <Output id="908" points="185 362" /> </Outputs> <Catalysts> <Catalyst id="503" points="273 418" /> </Catalysts> <Properties> <displayName>USP8 deubiquitinates LRIG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="517" reactomeId="8875451" points="1332 295, 1372 289, 1415 289" position="1372 289" lineWidth="1.0"> <Inputs> <Input id="896" points="1330 334" /> <Input id="891" points="1300 300" /> </Inputs> <Outputs> <Output id="898" points="1426 364" /> <Output id="899" points="1447 289" /> </Outputs> <Catalysts> <Catalyst id="891" points="1300 289, 1328 278" /> </Catalysts> <Properties> <displayName>MET phosphorylates CBL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="532" reactomeId="8875482" points="1758 383, 1760 409, 1745 457" position="1760 409" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="533" points="1679 403" /> <Input id="902" points="1758 358" /> </Inputs> <Outputs> <Output id="534" /> </Outputs> <Properties> <displayName>CBL recruits CIN85:endophilin to ubiquitinated MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="579" reactomeId="8875490" points="1515 577, 1518 616, 1512 672" position="1518 616" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="580" points="1422 539" /> <Input id="583" points="1438 589" /> </Inputs> <Outputs> <Output id="584" /> </Outputs> <Properties> <displayName>EPS15 and HGS bind ubiquitinated MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="581" points="318 287, 367 386, 769 528, 1126 470, 1280 502" position="769 528" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="481" /> </Inputs> <Outputs> <Output id="580" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="582" points="1627 500, 1422 511" position="1524 505" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="534" /> </Inputs> <Outputs> <Output id="580" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="585" reactomeId="8875523" points="535 496, 516 510, 168 472" position="516 510" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="586" points="434 475" /> <Input id="84" points="651 316" /> </Inputs> <Outputs> <Output id="587" /> </Outputs> <Properties> <displayName>MET binds TNS3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="588" reactomeId="8875531" points="535 533, 173 509" position="535 533" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="84" points="653 316" /> <Input id="589" points="97 542" /> </Inputs> <Outputs> <Output id="590" /> </Outputs> <Properties> <displayName>MET binds TNS4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="604" reactomeId="8875540" points="1201 1406, 1307 1381, 1386 1370" position="1307 1381" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="605" points="1114 1381" /> <Input id="300" points="1224 1421" /> </Inputs> <Outputs> <Output id="606" /> </Outputs> <Properties> <displayName>GAB1 recruits CRK,CRKL to MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="623" reactomeId="8875558" points="1464 1312, 1488 1307, 1533 1297" position="1488 1307" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="624" points="1447 1253" /> <Input id="606" points="1471 1330" /> </Inputs> <Outputs> <Output id="625" /> </Outputs> <Properties> <displayName>RAPGEF1 binds CRK,CRKL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="644" reactomeId="8875568" points="1610 1420, 1640 1422, 1676 1416" position="1640 1422" lineWidth="1.0"> <Inputs> <Input id="645" points="1580 1423" /> <Input id="648" points="1598 1451" /> </Inputs> <Outputs> <Output id="646" points="1709 1415" /> <Output id="650" points="1688 1446" /> </Outputs> <Catalysts> <Catalyst id="625" points="1635 1308" /> </Catalysts> <Properties> <displayName>RAPGEF1 activates RAP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="675" reactomeId="8875576" points="1371 1284, 1421 1226, 1497 1129" position="1421 1226" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="676" points="1348 1243" /> <Input id="606" points="1442 1330" /> </Inputs> <Outputs> <Output id="677" /> </Outputs> <Properties> <displayName>CRK,CRKL recruits RAC1 GEF to activated MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="692" reactomeId="8875591" points="1600 1189, 1648 1179, 1683 1183" position="1648 1179" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="693" points="1578 1183" /> <Input id="698" points="1561 1207" /> </Inputs> <Outputs> <Output id="694" points="1719 1170" /> <Output id="696" points="1734 1211" /> </Outputs> <Catalysts> <Catalyst id="677" points="1563 1129" /> </Catalysts> <Properties> <displayName>DOCK7 activates RAC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="736" reactomeId="8875661" points="414 1199, 453 1186, 508 1152" position="453 1186" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="737" points="378 1121" /> <Input id="738" points="447 1126" /> <Input id="606" points="1466 1389, 1353 1576, 584 1578" /> </Inputs> <Outputs> <Output id="739" /> </Outputs> <Properties> <displayName>GGA3 associates with activated MET receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="743" reactomeId="8875659" points="578 1071, 611 725, 660 316" position="611 725" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="739" /> </Inputs> <Outputs> <Output id="84" /> </Outputs> <Activators> <Activator id="746" points="461 997, 542 723" /> </Activators> <Properties> <displayName>RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="816" reactomeId="8875816" points="594 594, 338 963, 246 1441" position="338 963" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="817" points="528 633" /> <Input id="84" points="658 316" /> </Inputs> <Outputs> <Output id="818" /> </Outputs> <Properties> <displayName>STAT3 binds activated MET receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="819" reactomeId="8875817" points="283 1413, 322 1416, 354 1412" position="322 1416" lineWidth="1.0"> <Inputs> <Input id="818" points="258 1441" /> <Input id="820" points="292 1396" /> </Inputs> <Outputs> <Output id="84" points="659 316, 603 630, 540 707, 373 939, 323 1108, 405 1264" /> <Output id="821" points="376 1408" /> <Output id="822" points="340 1301" /> </Outputs> <Catalysts> <Catalyst id="818" points="317 1448, 343 1443" /> </Catalysts> <Properties> <displayName>MET phosphorylates STAT3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="825" reactomeId="2730595" points="327 1269, 229 1157, 245 1112" position="229 1157" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="822" stoichiometry="2" /> </Inputs> <Outputs> <Output id="826" /> </Outputs> <Properties> <displayName>Phosphorylated STAT3 Forms Dimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="827" reactomeId="2730599" points="251 1070, 257 932, 286 861" position="257 932" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="826" /> </Inputs> <Outputs> <Output id="828" /> </Outputs> <Properties> <displayName>Phosphorylated STAT3 Dimer Translocates to the Nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="890" points="671 316, 766 516, 1181 436" position="766 516" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="84" /> </Inputs> <Outputs> <Output id="437" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="911" reactomeId="9734070" points="317 172, 411 159, 486 207" position="411 159" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="33" points="260 215" /> <Input id="912" points="393 85" /> </Inputs> <Outputs> <Output id="913" /> </Outputs> <Properties> <displayName>Anti-MET recombinant therapeutic antibodies bind MET</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="938" reactomeId="9735946" points="440 343, 440 274, 466 274" position="440 274" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="60" points="426 338" /> <Input id="951" stoichiometry="2" points="420 412" /> </Inputs> <Outputs> <Output id="940" /> </Outputs> <Properties> <displayName>Anti-MET small tyrosine kinase inhibitors bind MET</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of Signaling by MET (6806937)
