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Details on Person UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)

Class:Id	Reaction:6806674
_displayName	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)
_doRelease	TRUE
_timestamp	2015-11-20 15:10:56
authored	[InstanceEdit:6807514] D'Eustachio, Peter, 2015-11-02
catalystActivity	[CatalystActivity:6806376] prenyltransferase activity of UBIAD1 [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643770] prenyltransferase activity of UBIAD1 [endoplasmic reticulum membrane] Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:6806680] D'Eustachio, Peter, 2015-10-23
edited	[InstanceEdit:6807514] D'Eustachio, Peter, 2015-11-02
input	[SimpleEntity:6806657] GGPP [endoplasmic reticulum lumen] [SimpleEntity:6806891] menadione [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:6806648] Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats [LiteratureReference:6806672] Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1 [LiteratureReference:6806387] Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme [LiteratureReference:6806889] The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase
modified	[InstanceEdit:6806683] D'Eustachio, Peter, 2015-10-23 [InstanceEdit:6806823] D'Eustachio, Peter, 2015-10-25 [InstanceEdit:6806888] D'Eustachio, Peter, 2015-10-27 [InstanceEdit:6807513] D'Eustachio, Peter, 2015-11-02 [InstanceEdit:6807517] D'Eustachio, Peter, 2015-11-02 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)
output	[SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806656] PPi [endoplasmic reticulum lumen]
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6807515] Jassal, Bijay, 2015-11-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812498] R-HSA-6806674.3
summation	[Summation:6806824] UBIAD1 (UbiA prenyltransferase domain-containing protein 1) ...
(hasEvent)	[Pathway:6806664] Metabolism of vitamin K [Homo sapiens]
(precedingEvent)	[Reaction:159752] GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) [Homo sapiens] [Reaction:159761] GGCX gamma-carboxylates F7(21-466) (pro-factor VII) [Homo sapiens] [Reaction:159795] GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) [Homo sapiens] [Reaction:159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) [Homo sapiens] [Reaction:159819] GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) [Homo sapiens] [Reaction:159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) [Homo sapiens] [Reaction:163810] GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) [Homo sapiens] [Reaction:163820] GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) [Homo sapiens] [Reaction:6807214] GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) [Homo sapiens]
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No pathways have been reviewed or authored by UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (6806674)