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Details on Person Keratin filaments are packed into bundles of varying diamete...
| Class:Id | Summation:6806634 |
|---|---|
| _displayName | Keratin filaments are packed into bundles of varying diamete... |
| _timestamp | 2016-08-12 11:28:28 |
| created | [InstanceEdit:6806627] Jupe, Steve, 2015-10-23 |
| literatureReference | [LiteratureReference:6806620] Molecular skin barrier models and some central problems for the understanding of skin barrier structure and function [LiteratureReference:6806628] Stratum corneum keratin structure, function, and formation: the cubic rod-packing and membrane templating model [LiteratureReference:8934827] X-rays Reveal the Internal Structure of Keratin Bundles in Whole Cells [LiteratureReference:6806612] Structural and regulatory functions of keratins [LiteratureReference:6809870] The small heat shock protein Hsp27 affects assembly dynamics and structure of keratin intermediate filament networks |
| modified | [InstanceEdit:6806636] Jupe, Steve, 2015-10-23 [InstanceEdit:6809858] Jupe, Steve, 2015-11-13 [InstanceEdit:8847957] Jupe, Steve, 2015-12-03 [InstanceEdit:8934782] Jupe, Steve, 2016-08-12 |
| text | Keratin filaments are packed into bundles of varying diameter, called tonofilament bundles. These are the building blocks of the cytoskeleton in epithelial cells. Each bundle is surrounded by polyribosomes and multivesicular or folded membrane complexes that form a branched, tubular network (Norlen et al. 2003). In the stratum corneum, keratin bundles are thought to pack in a cubic rod pattern (Norlen & Al-Amoudi 2004). In living cells, X-ray diffraction studies of keratin intermediate filaments indicate a filament radius of 5 nm, hexagonal geometric arrangement with an interfilament distance of 14 nm and bundle diameters of 70 nm (Hémonnot et al. 2016). Keratin filaments can rapidly disassemble and reassemble, allowing flexibility for the cytoskeleton. Keratin building blocks accumulate at the cell periphery near focal adhesions. Polymerization is regulated by signaling molecules, e.g. heat shock proteins, 14-3-3 proteins, kinases and phosphatases (Magin et al. 2007, Kayser et al. 2003). |
| (summation) | [Polymerisation:6806629] Formation of tonofilament bundles [Homo sapiens] |
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