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Details on Person TP53 and AP-1 stimulate MSH2 expression

Class:Id	BlackBoxEvent:6806394
_displayName	TP53 and AP-1 stimulate MSH2 expression
_doRelease	TRUE
_timestamp	2016-02-19 18:22:42
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6806398] Orlic-Milacic, Marija, 2015-10-22
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[EntityWithAccessionedSequence:6806564] MSH2 Gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6806409] p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV [LiteratureReference:6806400] Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells
modified	[InstanceEdit:6806570] Orlic-Milacic, Marija, 2015-10-23 [InstanceEdit:8856100] Orlic-Milacic, Marija, 2016-02-09 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 and AP-1 stimulate MSH2 expression
output	[EntityWithAccessionedSequence:5357525] MSH2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6806412] TP53 and AP-1 bind the MSH2 promoter [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:6806569] Positive gene expression regulation by 'AP-1:p-S15,S20-TP53 Tetramer:MSH2 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642890] Positive gene expression regulation by 'AP-1:p-S15,S20-TP53 Tetramer:MSH2 Gene [nucleoplasm]' p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861419] R-HSA-6806394.4
summation	[Summation:6806567] TP53 and the AP-1 transcription factor complex cooperatively...
(hasEvent)	[Pathway:6796648] TP53 Regulates Transcription of DNA Repair Genes [Homo sapiens]
(precedingEvent)	[Reaction:5444511] Formation of MSH2:MSH3 Complex [Homo sapiens] [Reaction:5444516] Formation of MSH2:MSH6 Complex [Homo sapiens]
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No pathways have been reviewed or authored by TP53 and AP-1 stimulate MSH2 expression (6806394)