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Details on Person Heat shock proteins (HSPs) are generally regarded as intrace...

Class:IdSummation:6805983
_displayNameHeat shock proteins (HSPs) are generally regarded as intrace...
_timestamp2015-10-21 09:29:12
created[InstanceEdit:6805948] Shamovsky, Veronica, 2015-10-21
literatureReference[LiteratureReference:6805985] Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4- and NF-kappaB-dependent mechanism
[LiteratureReference:6805971] Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4
[LiteratureReference:6805908] Activation of hepatocytes by extracellular heat shock protein 72
[LiteratureReference:6805900] TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells
[LiteratureReference:6805994] Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response
[LiteratureReference:6805889] Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4
[LiteratureReference:6805941] Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4
[LiteratureReference:6805951] Human myocardium releases heat shock protein 27 (HSP27) after global ischemia: the proinflammatory effect of extracellular HSP27 through toll-like receptor (TLR)-2 and TLR4
[LiteratureReference:181109] Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4
textHeat shock proteins (HSPs) are generally regarded as intracellular proteins acting as molecular chaperones; however, HSPs can also be released from cells during stress and injury. HSPs are believed to function as an endogenous danger signal by activating Toll-like receptor 4 in human, rodent cells and in animal models that mimic human cardiac disease (Asea A et al. 2002; Chase MA et al. 2007; Wheeler DS et al. 2009; Galloway E et al. 2008; Fang H et al. 2011, 2014; Li Y et al. 2011; Dybdahl B et al. 2002; Jin C et al. 2014).
(summation)[Reaction:6805932] HSPs bind TLR4:LY96 [Homo sapiens]
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