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Details on Person Diagram of Regulation of TP53 Activity through Association with Co-factors

Class:IdPathwayDiagram:6805499
_displayNameDiagram of Regulation of TP53 Activity through Association with Co-factors
_timestamp2024-02-26 21:12:30
created[InstanceEdit:6805500] Orlic-Milacic, Marija, 2015-10-19
height834
modified[InstanceEdit:6805614] Orlic-Milacic, Marija, 2015-10-20
[InstanceEdit:6805615] Orlic-Milacic, Marija, 2015-10-20
[InstanceEdit:6805767] Orlic-Milacic, Marija, 2015-10-21
[InstanceEdit:6805790] Orlic-Milacic, Marija, 2015-10-21
[InstanceEdit:6805795] Orlic-Milacic, Marija, 2015-10-21
[InstanceEdit:6806002] Orlic-Milacic, Marija, 2015-10-21
[InstanceEdit:6806093] Orlic-Milacic, Marija, 2015-10-21
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:9863011] Orlic-Milacic, Marija, 2024-02-26
representedPathway[Pathway:6804759] Regulation of TP53 Activity through Association with Co-factors [Homo sapiens]
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hideComponents="true"> <Properties> <displayName>Me2-K370,K382-TP53 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="55" reactomeId="3222249" position="356 601" bounds="284 582 145 38" textPosition="292 584" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PHF20:Me2-K370,K382-TP53 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="125" reactomeId="29358" position="545 566" bounds="525 554 40 25" textPosition="530 555"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="126" reactomeId="113582" position="550 642" bounds="530 628 41 28" textPosition="534 631"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="127" reactomeId="6805776" position="490 679" bounds="441 666 99 26" 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334, 1066 346" position="1023 334" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" points="689 260" /> <Input id="8" points="1067 166" /> </Inputs> <Outputs> <Output id="10" /> </Outputs> <Properties> <displayName>TP53 binds ZNF385A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11" reactomeId="6804402" points="803 449, 803 463, 898 475" position="803 463" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" points="646 271" /> <Input id="12" points="742 428" /> </Inputs> <Outputs> <Output id="13" /> </Outputs> <Properties> <displayName>TP53 binds POU4F1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14" reactomeId="6804425" points="563 503, 563 517, 615 526" position="563 517" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" points="627 271" /> <Input id="15" points="525 437" /> </Inputs> <Outputs> <Output id="16" /> </Outputs> <Properties> <displayName>TP53 binds POU4F2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="17" reactomeId="6799761" points="1269 484, 1327 485, 1403 489" position="1327 485" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="18" points="1192 492" /> <Input id="20" points="1278 439" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> <Properties> <displayName>TP53 binds PPP1R13L</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="19" points="666 271, 1086 474" position="876 372" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="4" /> </Inputs> <Outputs> <Output id="18" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="22" reactomeId="6799777" points="1259 587, 1283 586, 1447 589" position="1283 586" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="18" points="1155 525" /> <Input id="23" points="1235 628" /> </Inputs> <Outputs> <Output id="24" /> </Outputs> <Properties> <displayName>TP53 family members bind PPP1R13B or TP53BP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="34" reactomeId="3221982" points="229 236, 213 264, 190 321" position="213 264" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="35" points="189 190" /> <Input id="36" points="304 213" /> </Inputs> <Outputs> <Output id="37" /> </Outputs> <Properties> <displayName>BANP binds TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="39" interactionType="Activate" points="353 213, 414 249" position="383 231" lineWidth="2.0"> <Inputs> <Input id="36" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="40" interactionType="Activate" points="549 269, 575 262" position="562 265" lineWidth="2.0"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="4" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="52" reactomeId="3222259" points="353 516, 355 540, 355 579" position="355 540" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="53" points="445 503" /> <Input id="54" points="347 453" /> </Inputs> <Outputs> <Output id="55" /> </Outputs> <Properties> <displayName>PHF20 binds TP53 dimethylated on K370 and K382</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="124" reactomeId="6805785" points="474 563, 475 600, 483 634" position="475 600" lineWidth="1.0"> <Inputs> <Input id="53" points="472 514" /> <Input id="125" points="522 565" /> </Inputs> <Outputs> <Output id="126" points="527 639" /> <Output id="127" points="487 663" /> </Outputs> <Catalysts> <Catalyst id="128" points="603 600" /> </Catalysts> <Properties> <displayName>AKT phosphorylates PHF20</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="202" interactionType="Activate" points="1199 359, 1287 354" position="1243 356" lineWidth="2.0"> <Inputs> <Input id="10" /> </Inputs> <Outputs> <Output id="189" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="204" interactionType="Activate" points="1483 626, 1469 636" position="1476 631" lineWidth="2.0"> <Inputs> <Input id="24" /> </Inputs> <Outputs> <Output id="203" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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