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Details on Person PLK3 phosphorylates TP53

Class:Id	Reaction:6805285
_displayName	PLK3 phosphorylates TP53
_doRelease	TRUE
_timestamp	2017-02-23 17:23:53
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:3222175] protein serine/threonine kinase activity of PLK3 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6805284] Orlic-Milacic, Marija, 2015-10-19
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[Complex:349474] p-S15-TP53 Tetramer [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:3222166] Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3 [LiteratureReference:3222167] Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway
modified	[InstanceEdit:6805393] Orlic-Milacic, Marija, 2015-10-19 [InstanceEdit:8856532] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8979261] Orlic-Milacic, Marija, 2017-02-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PLK3 phosphorylates TP53
output	[Complex:3222171] p-S15,S20-TP53 Tetramer [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:6805470] AMPK phosphorylates TP53 [Homo sapiens] [Reaction:6804762] TP53 forms homotetramers [Homo sapiens] [Reaction:5693609] ATM phosphorylates TP53 at S15 [Homo sapiens] [Reaction:5693540] MRN activates ATM [Homo sapiens] [Reaction:5682026] MRN bound to shortened telomeres activates ATM [Homo sapiens] [Reaction:6804762] TP53 forms homotetramers [Homo sapiens] [Reaction:6799332] ATR phosphorylates TP53 [Homo sapiens] [Reaction:5685011] ATR activation at DNA DSBs [Homo sapiens] [Reaction:6804762] TP53 forms homotetramers [Homo sapiens] [Reaction:6805479] TP53RK phosphorylates TP53 [Homo sapiens] [Reaction:6804762] TP53 forms homotetramers [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861055] R-HSA-6805285.3
summation	[Summation:6805282] PLK3 contributes to stabilizing phosphorylation of TP53 on s...
(hasEvent)	[Pathway:6804756] Regulation of TP53 Activity through Phosphorylation [Homo sapiens]
(precedingEvent)	[Reaction:3215152] TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter [Homo sapiens] [Reaction:3215251] TP53INP1 and HIPK2 bind TP53 [Homo sapiens] [Reaction:3222093] BRD7 binds TP53 and EP300 [Homo sapiens] [Reaction:3222128] NOC2L binds TP53 [Homo sapiens] [Reaction:3222237] SMYD2 methylates TP53 [Homo sapiens] [Reaction:3700997] TP53 binds the MDM2 gene [Homo sapiens] [Reaction:4331331] TP53 binds the PMAIP1 (NOXA) promoter [Homo sapiens] [Reaction:5633295] TP53 binds the NDRG1 gene promoter [Homo sapiens] [Reaction:5633414] TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes [Homo sapiens] [Reaction:6791285] TP53 binds the BID gene promoter [Homo sapiens] List all 58 refering instances
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