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Details on Person CDK5 phosphorylates TP53

Class:Id	Reaction:6805276
_displayName	CDK5 phosphorylates TP53
_doRelease	TRUE
_timestamp	2017-02-23 16:05:06
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6805266] protein serine/threonine kinase activity of p-Y15,S159-CDK5:CDK5R1 (99-307) [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6805264] Orlic-Milacic, Marija, 2015-10-19
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[Complex:3209194] TP53 Tetramer [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:6805274] Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death [LiteratureReference:6805257] Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration [LiteratureReference:6805252] Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress [LiteratureReference:6805261] Cdk5 phosphorylates p53 and regulates its activity [LiteratureReference:8863438] Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation
modified	[InstanceEdit:8856532] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8863448] Orlic-Milacic, Marija, 2016-03-07 [InstanceEdit:8979252] Orlic-Milacic, Marija, 2017-02-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDK5 phosphorylates TP53
output	[SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [Complex:6805275] p-S15,S33,S46-TP53 Tetramer [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6804762] TP53 forms homotetramers [Homo sapiens] [BlackBoxEvent:6804188] PRDM1 represses TP53 expression [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861054] R-HSA-6805276.4
summation	[Summation:6805255] CDK5, in complex with cleaved CDK5R1 (p25), which ensures nu...
(hasEvent)	[Pathway:6804756] Regulation of TP53 Activity through Phosphorylation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783069] Update Tracker - [Reaction:6805276] CDK5 phosphorylates TP53 - v57:[addLiteratureReference]
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No pathways have been reviewed or authored by CDK5 phosphorylates TP53 (6805276)