Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person p14ARF sequesters MDM2

Class:IdReaction:6804996
_displayNamep14ARF sequesters MDM2
_doReleaseTRUE
_timestamp2019-05-06 20:31:04
authored[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:6804997] Orlic-Milacic, Marija, 2015-10-16
edited[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15
[InstanceEdit:4542306] Matthews, L, 2013-07-15
input[Complex:6804999] p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:3209191] ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
modified[InstanceEdit:8856346] Orlic-Milacic, Marija, 2016-02-09
[InstanceEdit:8861898] Orlic-Milacic, Marija, 2016-02-22
[InstanceEdit:9645195] Orlic-Milacic, Marija, 2019-05-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namep14ARF sequesters MDM2
output[Complex:3209194] TP53 Tetramer [nucleoplasm] [Homo sapiens]
[Complex:6804995] p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2013-09-18
reviewed[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8861048] R-HSA-6804996.3
summation[Summation:3245952] Binding of p14ARF to MDM2 decreases the half-life of MDM2, l...
(hasEvent)[Pathway:177037] p53 mediated events [Homo sapiens]
[Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens]
[Pathway:2559585] Oncogene Induced Senescence [Homo sapiens]
[Pathway:6804757] Regulation of TP53 Degradation [Homo sapiens]
(replacementInstances)[_Deleted:8932781] Deletion of instance: 69886
(updatedInstance)[_UpdateTracker:9777739] Update Tracker - [Reaction:6804996] p14ARF sequesters MDM2 - v69:[modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by p14ARF sequesters MDM2 (6804996)