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Details on Person p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm]

Class:IdComplex:6804885
_displayNamep-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm]
_timestamp2016-07-29 17:30:54
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:6804884] Orlic-Milacic, Marija, 2015-10-15
hasComponent
literatureReference[LiteratureReference:5633458] The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
[LiteratureReference:5633467] Amplification of a gene encoding a p53-associated protein in human sarcomas
[LiteratureReference:5633461] Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
[LiteratureReference:5633453] Mapping of the p53 and mdm-2 interaction domains
modified[InstanceEdit:8932752] Orlic-Milacic, Marija, 2016-07-28
[InstanceEdit:8932867] Orlic-Milacic, Marija, 2016-07-29
namep-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8859183] R-HSA-6804885.2
(hasComponent)[Complex:6804999] p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] [Homo sapiens]
(input)[Reaction:6804879] MDM2 ubiquitinates TP53 [Homo sapiens]
[Reaction:6804998] p14ARF forms a ternary complex with MDM2 and TP53 [Homo sapiens]
(output)[Reaction:5633460] MDM2 binds TP53 [Homo sapiens]
(physicalEntity)[CatalystActivity:6804883] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm]
(updatedInstance)[_UpdateTracker:9894992] Update Tracker - [Complex:6804885] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] - v58:[modifyName, updateContainedComponent]
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No pathways have been reviewed or authored by p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (6804885)
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