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Details on Person HMGB1 binds LPS

Class:Id	Reaction:6804100
_displayName	HMGB1 binds LPS
_doRelease	TRUE
_timestamp	2016-05-19 16:45:32
authored	[InstanceEdit:6797423] Shamovsky, Veronica, 2015-09-12
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:6804087] Shamovsky, Veronica, 2015-10-08
edited	[InstanceEdit:8870483] Shamovsky, Veronica, 2016-05-10
input	[EntityWithAccessionedSequence:6797422] HC23,45-HMGB1 [extracellular region] [Homo sapiens] [SimpleEntity:166005] LPS [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:6793861] High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes [LiteratureReference:6793853] High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts [LiteratureReference:6793764] HMGB1 signals through toll-like receptor (TLR) 4 and TLR2
modified	[InstanceEdit:6805948] Shamovsky, Veronica, 2015-10-21 [InstanceEdit:6809177] Shamovsky, Veronica, 2015-11-09 [InstanceEdit:6809989] Shamovsky, Veronica, 2015-11-13 [InstanceEdit:6810045] Shamovsky, Veronica, 2015-11-13 [InstanceEdit:8870483] Shamovsky, Veronica, 2016-05-10 [InstanceEdit:8870532] Shamovsky, Veronica, 2016-05-10 [InstanceEdit:8870808] Shamovsky, Veronica, 2016-05-12 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HMGB1 binds LPS
output	[Complex:6801229] HC23,45-HMGB1:LPS [extracellular region] [Homo sapiens]
precedingEvent	[BlackBoxEvent:6805981] HMGB1 release from cells [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:6797517] D'Eustachio, Peter, 2015-09-12 [InstanceEdit:8870806] Granucci, Francesca, Zanoni, Ivan
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873279] R-HSA-6804100.3
summation	[Summation:6804101] High mobility group box 1 (HMGB1) is an ubiquitous nuclear p...
(hasEvent)	[Pathway:5686938] Regulation of TLR by endogenous ligand [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782290] Update Tracker - [Reaction:6804100] HMGB1 binds LPS - v59:[modifyText] [_UpdateTracker:9864166] Update Tracker - [Reaction:6804100] HMGB1 binds LPS - v88:[modifyText]
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No pathways have been reviewed or authored by HMGB1 binds LPS (6804100)