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Details on Person PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA

Class:Id	Reaction:6803523
_displayName	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA
_doRelease	TRUE
_timestamp	2016-02-19 18:20:20
authored	[InstanceEdit:6803263] Rothfels, Karen, 2015-10-05
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6803520] Rothfels, Karen, 2015-10-06
edited	[InstanceEdit:6803263] Rothfels, Karen, 2015-10-05
input	[Complex:6803524] capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:71923] PTBP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:71927] HNRNPA1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6803449] An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein [LiteratureReference:6803454] Characterization of cDNAs encoding the polypyrimidine tract-binding protein [LiteratureReference:6803513] hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer [LiteratureReference:6803495] Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon
modified	[InstanceEdit:6808664] Rothfels, Karen, 2015-11-08 [InstanceEdit:6809487] Rothfels, Karen, 2015-11-11 [InstanceEdit:6809936] Rothfels, Karen, 2015-11-13 [InstanceEdit:8851417] Rothfels, Karen, 2016-01-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA
output	[Complex:6803522] FGFR2 IIIc-specific splicing complex [nucleoplasm] [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8851378] Grose, Richard P, 2016-01-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861057] R-HSA-6803523.2
summation	[Summation:6803507] Repression of FGFR2 exon IIIb splicing in mesenchymal cells ...
(hasEvent)	[Pathway:6803529] FGFR2 alternative splicing [Homo sapiens]
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No pathways have been reviewed or authored by PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (6803523)