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Details on Person PCBP4 binds the CDKN1A mRNA

Class:Id	Reaction:6803403
_displayName	PCBP4 binds the CDKN1A mRNA
_doRelease	TRUE
_timestamp	2018-10-31 15:07:34
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6803407] Orlic-Milacic, Marija, 2015-10-06
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14 [InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
input	[EntityWithAccessionedSequence:6803386] CDKN1A mRNA [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6803382] PCBP4 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6803408] The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability
modified	[InstanceEdit:6803414] Orlic-Milacic, Marija, 2015-10-06 [InstanceEdit:6804132] Orlic-Milacic, Marija, 2015-10-08 [InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809229] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809236] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6810438] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8856095] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9618019] Orlic-Milacic, Marija, 2018-08-31 [InstanceEdit:9625982] Orlic-Milacic, Marija, 2018-10-23 [InstanceEdit:9626979] Orlic-Milacic, Marija, 2018-10-30 [InstanceEdit:9626982] Orlic-Milacic, Marija, 2018-10-30 [InstanceEdit:9627017] Orlic-Milacic, Marija, 2018-10-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PCBP4 binds the CDKN1A mRNA
output	[Complex:6803405] PCBP4:CDKN1A mRNA [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:6803388] TP53 stimulates CDKN1A (p21) transcription [Homo sapiens] [Reaction:6803801] TP53 in complex with ZNF385A binds the CDKN1A promoter [Homo sapiens] [BlackBoxEvent:6803400] TP53 stimulates PCBP4 expression [Homo sapiens] [Reaction:6803391] TP53 binds the PCBP4 gene [Homo sapiens] [BlackBoxEvent:9617838] CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 [Homo sapiens] [Reaction:9617840] FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter [Homo sapiens] [Reaction:9618004] FOXO:SMAD complex binds CDKN1A gene promoter [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861171] R-HSA-6803403.3
summation	[Summation:6803410] PCBP4 binds the 3'-UTR of the CDKN1A (p21) mRNA and reduces ...
(hasEvent)	[Pathway:69895] Transcriptional activation of cell cycle inhibitor p21 [Homo sapiens] [Pathway:6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest [Homo sapiens] [Pathway:9617828] FOXO-mediated transcription of cell cycle genes [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:6803411] PCBP4 modulates CDKN1A translation [Homo sapiens]
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No pathways have been reviewed or authored by PCBP4 binds the CDKN1A mRNA (6803403)