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Details on Person Dissociation of paradoxically activated RAS:BRAF complexes

Class:Id	Reaction:6803234
_displayName	Dissociation of paradoxically activated RAS:BRAF complexes
_doRelease	TRUE
_timestamp	2016-08-05 12:20:51
authored	[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6803236] Rothfels, Karen, 2015-10-05
disease	[Disease:1500689] cancer
edited	[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
entityFunctionalStatus	[EntityFunctionalStatus:6803235] gain_of_function of RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]
input	[Complex:6802637] RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
modified	[InstanceEdit:6808681] Rothfels, Karen, 2015-11-09 [InstanceEdit:6809894] Rothfels, Karen, 2015-11-13 [InstanceEdit:8857993] Rothfels, Karen, 2016-02-17 [InstanceEdit:8861918] Rothfels, Karen, 2016-02-22 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933511] Rothfels, Karen, 2016-08-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of paradoxically activated RAS:BRAF complexes
normalReaction	[Reaction:5672980] Dissociation of RAS:RAF complex [Homo sapiens]
output	[CandidateSet:5672717] RAF/MAPK scaffolds [cytosol] [Homo sapiens] [DefinedSet:5672721] p-2S MAP2K homo/heterodimers [cytosol] [Homo sapiens] [DefinedSet:169289] p-T,Y MAPKs [cytosol] [Homo sapiens] [Complex:6802633] mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] [Homo sapiens]
releaseDate	2016-09-19
releaseStatus	NEW
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8919445] R-HSA-6803234.2
summation	[Summation:6803217] After phosphorylation by MAP2Ks, the scaffolded kinase compl...
(hasEvent)	[Pathway:6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF [Homo sapiens]
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No pathways have been reviewed or authored by Dissociation of paradoxically activated RAS:BRAF complexes (6803234)