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Details on Person Dissociation of oncogenic RAS:RAF complex

Class:Id	Reaction:6803233
_displayName	Dissociation of oncogenic RAS:RAF complex
_doRelease	TRUE
_timestamp	2016-08-05 12:20:44
authored	[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6803232] Rothfels, Karen, 2015-10-05
disease	[Disease:1500689] cancer [Disease:6802289] Noonan syndrome
edited	[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
entityFunctionalStatus	[EntityFunctionalStatus:6803231] gain_of_function of mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]
input	[Complex:6802672] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling [LiteratureReference:6799045] Dragging ras back in the ring
modified	[InstanceEdit:6808680] Rothfels, Karen, 2015-11-09 [InstanceEdit:6809892] Rothfels, Karen, 2015-11-13 [InstanceEdit:8857992] Rothfels, Karen, 2016-02-17 [InstanceEdit:8861917] Rothfels, Karen, 2016-02-22 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933510] Rothfels, Karen, 2016-08-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of oncogenic RAS:RAF complex
normalReaction	[Reaction:5672980] Dissociation of RAS:RAF complex [Homo sapiens]
output	[CandidateSet:5672717] RAF/MAPK scaffolds [cytosol] [Homo sapiens] [DefinedSet:5672721] p-2S MAP2K homo/heterodimers [cytosol] [Homo sapiens] [DefinedSet:169289] p-T,Y MAPKs [cytosol] [Homo sapiens] [Complex:6802617] RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:6802922] Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS [Homo sapiens] [Reaction:6802926] Mutant RAS:p-RAF complexes phosphorylate MAP2Ks [Homo sapiens]
releaseDate	2016-09-19
releaseStatus	NEW
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8923248] R-HSA-6803233.2
summation	[Summation:6803224] After phosphorylation by MAP2Ks, the scaffolded kinase compl...
(hasEvent)	[Pathway:9649948] Signaling downstream of RAS mutants [Homo sapiens]
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