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Details on Person Inhibitors bind and inhibit highly active BRAF mutants

Class:Id	Reaction:6802938
_displayName	Inhibitors bind and inhibit highly active BRAF mutants
_doRelease	TRUE
_timestamp	2019-06-25 14:56:07
authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6802939] Rothfels, Karen, 2015-10-02
disease	[Disease:1500689] cancer [Disease:9651119] cardiofaciocutaneous syndrome
edited	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
entityFunctionalStatus	[EntityFunctionalStatus:6802883] gain_of_function of high kinase activity BRAF mutants [cytosol]
input	[DefinedSet:6802579] high kinase activity BRAF mutants [cytosol] [Homo sapiens] [CandidateSet:6802559] BRAF inhibitors [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6790256] Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885 [LiteratureReference:6790292] Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
modified	[InstanceEdit:6808686] Rothfels, Karen, 2015-11-09 [InstanceEdit:6809899] Rothfels, Karen, 2015-11-13 [InstanceEdit:8857998] Rothfels, Karen, 2016-02-17 [InstanceEdit:8861923] Rothfels, Karen, 2016-02-22 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933517] Rothfels, Karen, 2016-08-05 [InstanceEdit:9651237] Rothfels, Karen, 2019-06-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Inhibitors bind and inhibit highly active BRAF mutants
output	[Complex:6802578] BRAF inhibitors:high kinase activity BRAF mutants [cytosol] [Homo sapiens]
releaseDate	2016-09-19
releaseStatus	NEW
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8930693] R-HSA-6802938.3
summation	[Summation:6802240] The class I ATP competitive inhibitors vemurafenib and dabra...
(hasEvent)	[Pathway:6802948] Signaling by high-kinase activity BRAF mutants [Homo sapiens]
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No pathways have been reviewed or authored by Inhibitors bind and inhibit highly active BRAF mutants (6802938)