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Details on Person Inactive BRAF mutants bind mutant RAS:GTP

Class:Id	Reaction:6802937
_displayName	Inactive BRAF mutants bind mutant RAS:GTP
_doRelease	TRUE
_timestamp	2016-08-23 15:12:05
authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6802936] Rothfels, Karen, 2015-10-02
disease	[Disease:1500689] cancer
edited	[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
entityFunctionalStatus	[EntityFunctionalStatus:6802880] gain_of_function of genetically or chemically inactive BRAF [cytosol]
input	[DefinedSet:6802631] genetically or chemically inactive BRAF [cytosol] [Homo sapiens] [Complex:6802607] RAS mutants:GTP [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6790314] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling [LiteratureReference:5672195] Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF [LiteratureReference:6790390] RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF [LiteratureReference:6790370] RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth [LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:6790322] Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling [LiteratureReference:6790420] Targeting RAS-ERK signalling in cancer: promises and challenges [LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
modified	[InstanceEdit:6808685] Rothfels, Karen, 2015-11-09 [InstanceEdit:6809437] Rothfels, Karen, 2015-11-11 [InstanceEdit:6809898] Rothfels, Karen, 2015-11-13 [InstanceEdit:8857997] Rothfels, Karen, 2016-02-17 [InstanceEdit:8861922] Rothfels, Karen, 2016-02-22 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933516] Rothfels, Karen, 2016-08-05 [InstanceEdit:8936762] Rothfels, Karen, 2016-08-23 [InstanceEdit:8936767] Rothfels, Karen, 2016-08-23 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Inactive BRAF mutants bind mutant RAS:GTP
normalReaction	[Reaction:5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP [Homo sapiens]
output	[Complex:8936725] chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] [Homo sapiens]
regulatedBy	[PositiveRegulation:8936744] Positive regulation by 'PHB [cytosol]'
releaseDate	2016-09-19
releaseStatus	NEW
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8915266] R-HSA-6802937.3
summation	[Summation:6802246] The paradoxical activation of ERK signaling downstream of ki...
(hasEvent)	[Pathway:6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF [Homo sapiens]
(precedingEvent)	[Reaction:8936731] Inactive BRAF mutants:mutant RAS:GTP bind RAF1 [Homo sapiens]
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