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Details on Person RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]

Class:Id	Complex:6802648
_displayName	RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]
_timestamp	2018-02-20 20:43:59
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6802649] Rothfels, Karen, 2015-10-02
hasComponent	[CandidateSet:5672717] RAF/MAPK scaffolds [cytosol] [Homo sapiens] [DefinedSet:169289] p-T,Y MAPKs [cytosol] [Homo sapiens] [Complex:6802642] RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] [Homo sapiens] [Complex:167204] RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol] [DefinedSet:109782] RAS [plasma membrane] [Homo sapiens] [CandidateSet:6802641] moderate kinase activity BRAF mutants [cytosol] [Homo sapiens] [DefinedSet:8936667] phosphorylated RAFs:YWHAB [plasma membrane] [Homo sapiens] [DefinedSet:5672721] p-2S MAP2K homo/heterodimers [cytosol] [Homo sapiens]
includedLocation	[Compartment:70101] cytosol
isChimeric	FALSE
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9037747] Rothfels, Karen, 2018-02-20
name	RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8887226] R-HSA-6802648.2
(diseaseEntity)	[EntityFunctionalStatus:6803228] gain_of_function of RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]
(input)	[Reaction:6803230] Dissociation of moderate activity BRAF complexes [Homo sapiens]
(output)	[Reaction:6802921] Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9896082] Update Tracker - [Complex:6802648] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v60:[updateContainedComponent] [_UpdateTracker:9898565] Update Tracker - [Complex:6802648] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v64:[add_removeHasComponent, updateContainedComponent] [_UpdateTracker:9899665] Update Tracker - [Complex:6802648] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v67:[updateContainedComponent] [_UpdateTracker:9900760] Update Tracker - [Complex:6802648] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v70:[updateContainedComponent] [_UpdateTracker:9919817] Update Tracker - [Complex:6802648] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v90:[updateContainedComponent] [_UpdateTracker:9928541] Update Tracker - [Complex:6802648] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] - v91:[updateContainedComponent]
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No pathways have been reviewed or authored by RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (6802648)