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Details on Person RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane]

Class:Id	Complex:6802642
_displayName	RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane]
_timestamp	2016-08-22 18:42:11
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6802643] Rothfels, Karen, 2015-10-02
disease	[Disease:1500689] cancer
hasComponent	[Complex:167204] RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol] [DefinedSet:109782] RAS [plasma membrane] [Homo sapiens] [CandidateSet:6802641] moderate kinase activity BRAF mutants [cytosol] [Homo sapiens] [DefinedSet:8936667] phosphorylated RAFs:YWHAB [plasma membrane] [Homo sapiens]
includedLocation	[Compartment:70101] cytosol
isChimeric	FALSE
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8936685] Rothfels, Karen, 2016-08-22
name	RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8927773] R-HSA-6802642.1
(diseaseEntity)	[EntityFunctionalStatus:6802874] gain_of_function of RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane]
(hasComponent)	[Complex:6802645] RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] [Homo sapiens] [Complex:6802647] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] [Homo sapiens] [Complex:6802648] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] [Homo sapiens]
(input)	[Reaction:6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs [Homo sapiens]
(output)	[Reaction:6802916] RAF is phosphorylated downstream of moderate kinase activity BRAF mutants [Homo sapiens] [Reaction:6803230] Dissociation of moderate activity BRAF complexes [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9900632] Update Tracker - [Complex:6802642] RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] - v70:[updateContainedComponent]
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No pathways have been reviewed or authored by RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane] (6802642)