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Details on Person Regenerating islet-derived 3 (REG3) proteins belong to the f...

Class:Id	Summation:6801770
_displayName	Regenerating islet-derived 3 (REG3) proteins belong to the f...
_timestamp	2016-04-15 12:23:38
created	[InstanceEdit:6801765] Shamovsky, Veronica, 2015-10-02
literatureReference	[LiteratureReference:6801784] Molecular basis for peptidoglycan recognition by a bactericidal lectin [LiteratureReference:6801767] Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation [LiteratureReference:6801768] Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment [LiteratureReference:6801772] Symbiotic bacteria direct expression of an intestinal bactericidal lectin [LiteratureReference:6801793] Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coli
modified	[InstanceEdit:8867536] Jupe, Steve, 2016-04-15
text	Regenerating islet-derived 3 (REG3) proteins belong to the family of C-type lectins (Cash HL et al. 2006a,b; Lehotzky RE et al. 2010). REG3A and REG3G are expressed in the intestine where they moodulate the host interactions with commensal and pathogenic gut bacteria. REG3 proteins bind the peptidoglycan moieties of bacteria inducing damage to the bacterial cell wall. The antibacterial activities of REG3 proteins are restricted to Gram-positive bacteria and are tightly controlled by an inhibitory N-terminal prosegment that is removed by trypsin in vivo (Cash HL et al. 2006; Mukherjee S et al. 2009; Medveczky P et al. 2009).
(summation)	[BlackBoxEvent:6801766] Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) [Homo sapiens]
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