Query author contributions in Reactome
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Details on Person The binding of TP53 (p53) to the p53 response element in the...
| Class:Id | Summation:6801414 |
|---|---|
| _displayName | The binding of TP53 (p53) to the p53 response element in the... |
| _timestamp | 2015-10-05 16:43:32 |
| created | [InstanceEdit:6801413] Orlic-Milacic, Marija, 2015-10-01 |
| modified | [InstanceEdit:6801450] Orlic-Milacic, Marija, 2015-10-01 [InstanceEdit:6803275] Orlic-Milacic, Marija, 2015-10-05 |
| text | The binding of TP53 (p53) to the p53 response element in the promoter of the NLRC4 (Ipaf) gene promotes NLRC4 transcription. NLRC4 is an activator of caspase-1 (CASP1) (Poyet et al. 2001), which is also a TP53 target. NLRC4 and CASP1 play an important role in innate immunity via inflammasome-mediated destruction of pathogenic bacteria and fungi (Schroder and Tschopp 2010). NLRC4 contributes to cell death (Sadasivam et al. 2005), possibly through interleukin-1-mediated pyroptosis (Brough and Rothwell 2007). |
| (summation) | [BlackBoxEvent:6801415] TP53 stimulates NLRC4 expression [Homo sapiens] |
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No pathways have been reviewed or authored by The binding of TP53 (p53) to the p53 response element in the... (6801414)
