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Details on Person CHM binds RGGT

Class:Id	Reaction:6801109
_displayName	CHM binds RGGT
_doRelease	TRUE
_timestamp	2016-02-19 18:20:39
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:6801110] Orlic-Milacic, Marija, 2015-09-30
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[Complex:6801105] RGGT [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6801097] CHM [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6801102] Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate [LiteratureReference:6801119] Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1 [LiteratureReference:6801137] Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A [LiteratureReference:6801133] Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors [LiteratureReference:6801140] A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy
modified	[InstanceEdit:6801120] Orlic-Milacic, Marija, 2015-09-30 [InstanceEdit:6801159] Orlic-Milacic, Marija, 2015-09-30 [InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809229] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809233] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6810430] Orlic-Milacic, Marija, 2015-11-16 [InstanceEdit:6810437] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8856083] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CHM binds RGGT
output	[Complex:6801111] RGGT:CHM [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:6801101] RABGGTA binds RABGGTB [Homo sapiens] [BlackBoxEvent:6801089] TP53 stimulates RABGGTA expression [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861114] R-HSA-6801109.2
summation	[Summation:6801112] RAB escort protein CHM (REP1) binds the RAB geranylgeranyl t...
(hasEvent)	[Pathway:6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain [Homo sapiens]
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No pathways have been reviewed or authored by CHM binds RGGT (6801109)