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Details on Person A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation
| Class:Id | LiteratureReference:6800629 |
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| _displayName | A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation |
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| _timestamp | 2015-09-29 16:49:57 |
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| author | [Person:6800561] Lee, Nathan V
[Person:266325] Lira, ME
[Person:6800586] Pavlicek, Adam
[Person:6800626] Ye, Jingjing
[Person:6800505] Buckman, Dana
[Person:5672567] Bagrodia, Shubha
[Person:6800607] Srinivasa, Sreesha P
[Person:6800628] Zhao, Yongjun
[Person:6800494] Aparicio, Samuel
[Person:508367] Rejto, PA
[Person:6800518] Christensen, James G
[Person:6800515] Ching, Keith A |
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| created | [InstanceEdit:6800630] Rothfels, Karen, 2015-09-29 |
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| journal | PLoS ONE |
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| pages | e39653 |
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| pubMedIdentifier | 22745804 |
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| title | A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation |
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| volume | 7 |
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| year | 2012 |
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| (literatureReference) | [EntityWithAccessionedSequence:6802469] SND1(1-593)-BRAF(381-766) fusion [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:6802552] SND1(1-593)-p-BRAF(381-766) fusion [cytosol] [Homo sapiens]
[Reaction:6802927] BRAF and RAF fusion mutant dimers are phosphorylated [Homo sapiens]
[Reaction:6802932] Dissociation of BRAF/RAF fusion complex [Homo sapiens]
[Reaction:6802933] p-BRAF and RAF fusion dimers phosphorylate MAP2Ks [Homo sapiens]
[Reaction:6802934] p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs [Homo sapiens]
[Reaction:6802935] MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers [Homo sapiens]
[Pathway:6802952] Signaling by BRAF and RAF1 fusions [Homo sapiens] |
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