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Details on Person HPN heterodimer cleaves pro-HGF to form HGF dimer

Class:Id	Reaction:6800200
_displayName	HPN heterodimer cleaves pro-HGF to form HGF dimer
_doRelease	TRUE
_timestamp	2016-07-18 20:13:06
authored	[InstanceEdit:6800142] Jassal, Bijay, 2015-09-28
catalystActivity	[CatalystActivity:6800204] serine-type endopeptidase activity of HPN heterodimer [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:6800223] Jassal, Bijay, 2015-09-28
edited	[InstanceEdit:6800142] Jassal, Bijay, 2015-09-28 [InstanceEdit:8931741] Orlic-Milacic, Marija, 2016-07-18
input	[EntityWithAccessionedSequence:6800218] pro-HGF [extracellular region] [Homo sapiens] [SimpleEntity:109276] H2O [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:6800228] Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization [LiteratureReference:6800222] Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth [LiteratureReference:6800220] Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2 [LiteratureReference:8931747] Hepsin promotes prostate cancer progression and metastasis [LiteratureReference:8931753] A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis [LiteratureReference:8931748] Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor [LiteratureReference:8931756] Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor
modified	[InstanceEdit:6800318] Jassal, Bijay, 2015-09-29 [InstanceEdit:8849218] Jassal, Bijay, 2015-12-14 [InstanceEdit:8851786] Jassal, Bijay, 2016-01-11 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8931761] Orlic-Milacic, Marija, 2016-07-18 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HPN heterodimer cleaves pro-HGF to form HGF dimer
output	[Complex:141763] HGF dimer [extracellular region] [Homo sapiens]
regulatedBy	[NegativeRegulation:6800234] Negative regulation by 'SPINT1,2 [extracellular region]'
releaseDate	2016-03-23
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11 [InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8882284] R-HSA-6800200.3
summation	[Summation:6800209] Hepsin (HPN, aka TMPRSS1) is a cell surface-expressed chymot...
(hasEvent)	[Pathway:6806942] MET Receptor Activation [Homo sapiens]
(precedingEvent)	[Reaction:6800298] HGF dimer binds MET [Homo sapiens]
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