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Details on Person SREBP1A,1C binds the SCD gene

Class:IdReaction:6800052
_displayNameSREBP1A,1C binds the SCD gene
_doReleaseTRUE
_timestamp2026-04-13 17:35:17
authored[InstanceEdit:6800048] May, Bruce, 2015-09-27
catalystActivity[CatalystActivity:9987248] DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,1C dimer [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9987245] DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,1C dimer [nucleoplasm] Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:6800050] May, Bruce, 2015-09-27
edited[InstanceEdit:6800048] May, Bruce, 2015-09-27
input[EntityWithAccessionedSequence:6800051] SCD gene [nucleoplasm] [Homo sapiens]
[Complex:2065537] SREBP1A,1C dimer [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9987328] D'Eustachio, Peter, 2026-04-13
isChimericFALSE
literatureReference[LiteratureReference:1655587] Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes
[LiteratureReference:1655678] Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol
[LiteratureReference:1655604] Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2
[LiteratureReference:1655613] SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
[LiteratureReference:1655615] Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
modified[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9987236] D'Eustachio, Peter, 2026-04-10
[InstanceEdit:9987329] D'Eustachio, Peter, 2026-04-13
[InstanceEdit:9987332] D'Eustachio, Peter, 2026-04-13
nameSREBP1A,1C binds the SCD gene
output[Complex:1655743] SREBP1A,1C:SCD gene [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2015-12-15
releaseStatusNEW
reviewed[InstanceEdit:6800048] May, Bruce, 2015-09-27
[InstanceEdit:9987331] Hill, David P, 2026-04-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6812491] R-HSA-6800052.3
structureModified[InstanceEdit:9987236] D'Eustachio, Peter, 2026-04-10
summation[Summation:6800053] SREBF1A (SREBP1A) and SREBF1C (SREBP1C) bind the promoter of...
(hasEvent)[Pathway:2426168] Activation of gene expression by SREBF (SREBP) [Homo sapiens]
(precedingEvent)[BlackBoxEvent:1655849] Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9989658] Update Tracker - [Reaction:6800052] SREBP1A,1C binds the SCD gene - v97:[addCatalystActivity]
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No pathways have been reviewed or authored by SREBP1A,1C binds the SCD gene (6800052)
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