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Details on Person TP53I3 oxidoreductase generates unstable semiquinones

Class:Id	Reaction:6799722
_displayName	TP53I3 oxidoreductase generates unstable semiquinones
_doRelease	TRUE
_timestamp	2020-02-24 15:20:30
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6799729] quinone reductase (NADPH) activity of TP53I3 Dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9644083] NADPH:quinone reductase activity of TP53I3 Dimer [cytosol] Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6799724] Orlic-Milacic, Marija, 2015-09-25
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[SimpleEntity:6799725] 1,2-Naphthoquinone [cytosol] [SimpleEntity:6799725] 1,2-Naphthoquinone [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6799444] Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3
modified	[InstanceEdit:6803274] Orlic-Milacic, Marija, 2015-10-05 [InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809229] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809233] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6810435] Orlic-Milacic, Marija, 2015-11-16 [InstanceEdit:6810437] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8856083] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8979248] Orlic-Milacic, Marija, 2017-02-23 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9676940] Orlic-Milacic, Marija, 2020-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53I3 oxidoreductase generates unstable semiquinones
output	[SimpleEntity:6799726] semiquinone [cytosol] [SimpleEntity:6799726] semiquinone [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:6799466] TP53I3 dimerizes [Homo sapiens] [BlackBoxEvent:6799441] TP53 stimulates expression of the TP53I3 (PIG3) gene [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861121] R-HSA-6799722.5
summation	[Summation:6799727] TP53I3 (PIG3) possesses a NADPH quinone reductase activity, ...
(hasEvent)	[Pathway:6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain [Homo sapiens]
(precedingEvent)	[Reaction:6799733] Semiquinone reacts with oxygen [Homo sapiens]
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