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Details on Person GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P

Class:Id	Reaction:6799604
_displayName	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P
_doRelease	TRUE
_timestamp	2025-02-20 02:59:46
authored	[InstanceEdit:6799603] Jassal, Bijay, 2015-09-25
catalystActivity	[CatalystActivity:6799599] glucosamine-6-phosphate deaminase activity of GNPDA1,2 hexamers [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6799603] Jassal, Bijay, 2015-09-25
crossReference	[DatabaseIdentifier:9933520] RHEA:12173
edited	[InstanceEdit:6799603] Jassal, Bijay, 2015-09-25
goBiologicalProcess	[GO_BiologicalProcess:14877] glucosamine catabolic process
input	[SimpleEntity:449701] GlcN6P [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6799651] Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity [LiteratureReference:6799660] Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin [LiteratureReference:6799668] Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study
modified	[InstanceEdit:6799665] Jassal, Bijay, 2015-09-25 [InstanceEdit:8851786] Jassal, Bijay, 2016-01-11 [InstanceEdit:8982686] D'Eustachio, Peter, 2017-03-21 [InstanceEdit:9639641] D'Eustachio, Peter, 2019-03-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9933517] Stephan, Ralf, 2025-01-01 [InstanceEdit:9938833] Matthews, Lisa, 2025-02-20
name	GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P
output	[SimpleEntity:29512] Fru(6)P [cytosol] [SimpleEntity:31633] NH4+ [cytosol]
precedingEvent	[Reaction:6803789] AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA [Homo sapiens] [Reaction:6803771] NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P [Homo sapiens] [Reaction:449715] GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P [Homo sapiens] [Reaction:70471] GPI dimer isomerizes G6P [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861126] R-HSA-6799604.5
summation	[Summation:6799661] Glucosamine-6-phosphate isomerases 1 and 2 (GNPDA1, 2) catal...
(hasEvent)	[Pathway:70171] Glycolysis [Homo sapiens]
(precedingEvent)	[Reaction:70467] PFK tetramer phosphorylates Fru(6)P [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780933] Update Tracker - [Reaction:6799604] GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P - v61:[add_removeOutput]
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