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Details on Person MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man

Class:Id	Reaction:6799581
_displayName	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man
_doRelease	TRUE
_timestamp	2016-02-19 18:20:42
authored	[InstanceEdit:6799498] Jassal, Bijay, 2015-09-25
catalystActivity	[CatalystActivity:6799586] mannan endo-1,6-alpha-mannosidase activity of MAN2B2:Zn2+ [lysosomal lumen]
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:6799574] Jassal, Bijay, 2015-09-25
edited	[InstanceEdit:6799498] Jassal, Bijay, 2015-09-25
input	[SimpleEntity:6799577] alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc [lysosomal lumen] [SimpleEntity:1605715] H2O [lysosomal lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:6799587] Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties [LiteratureReference:6799580] Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism
modified	[InstanceEdit:6799595] Jassal, Bijay, 2015-09-25 [InstanceEdit:6799596] Jassal, Bijay, 2015-09-25 [InstanceEdit:8851786] Jassal, Bijay, 2016-01-11 [InstanceEdit:8853700] Jassal, Bijay, 2016-01-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man
output	[SimpleEntity:8853719] GlcNAc:Man [lysosomal lumen] [SimpleEntity:6799594] Man [lysosomal lumen] [SimpleEntity:6799594] Man [lysosomal lumen]
precedingEvent	[Reaction:8853686] MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 [Homo sapiens] [BlackBoxEvent:8853391] GlcNAc (Man)5 translocates from cytosol to lysosomal lumen [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861125] R-HSA-6799581.2
summation	[Summation:6799583] Endoplasmic reticulum-associated degradation of misfolded gl...
(hasEvent)	[Pathway:8853383] Lysosomal oligosaccharide catabolism [Homo sapiens]
(precedingEvent)	[Reaction:8853710] MANBA hydrolyses GlcNAc:Man [Homo sapiens]
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No pathways have been reviewed or authored by MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (6799581)