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Details on Person D-glyceric acid (DGA) is an intermediate of serine catabolis...
| Class:Id | Summation:6799492 |
|---|---|
| _displayName | D-glyceric acid (DGA) is an intermediate of serine catabolis... |
| _timestamp | 2023-05-16 19:03:51 |
| created | [InstanceEdit:6799498] Jassal, Bijay, 2015-09-25 |
| modified | [InstanceEdit:9835577] D'Eustachio, Peter, 2023-05-16 |
| text | D-glyceric acid (DGA) is an intermediate of serine catabolism and of a minor pathway of fructose metabolism. The only known fate of DGA is phosphorylation to 3-phospho-D-glyceric acid (3PDGA) by cytosolic glycerate kinase (GLYCTK) (Yu et al. 2006). Defects in GLYCTK can cause D-glyceric aciduria (D-GA; MIM:220120), a rare inborn error of serine and fructose metabolism where DGA is excreted in large amounts in the urine. A variable phenotype is observed, ranging from severe mental retardation and death to milder speech delays and normal development (Van Schaftingen 1989, Sass et al. 2010). |
| (summation) | [Reaction:6799495] GLYCTK phosphorylates DGA to 3PDGA [Homo sapiens] |
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