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Details on Person HIPK2 phosphorylates TP53

Class:Id	Reaction:6799409
_displayName	HIPK2 phosphorylates TP53
_doRelease	TRUE
_timestamp	2016-02-19 18:20:43
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6799405] protein serine/threonine kinase activity of TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6799385] Orlic-Milacic, Marija, 2015-09-24
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [Complex:3215242] TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6799406] Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis [LiteratureReference:6799394] Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 [LiteratureReference:3215228] TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity [LiteratureReference:3215254] p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis
modified	[InstanceEdit:6799423] Orlic-Milacic, Marija, 2015-09-24 [InstanceEdit:6799426] Orlic-Milacic, Marija, 2015-09-24 [InstanceEdit:6799439] Orlic-Milacic, Marija, 2015-09-24 [InstanceEdit:8856532] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HIPK2 phosphorylates TP53
output	[Complex:6798371] p-S15,S20,S46-TP53 Tetramer [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [Complex:6799392] p-HIPK2:PIN1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3215226] TP53INP1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:3215251] TP53INP1 and HIPK2 bind TP53 [Homo sapiens] [BlackBoxEvent:6799416] TP53 stimulates expression of TP53INP1 [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861127] R-HSA-6799409.2
summation	[Summation:6799381] HIPK2, activated by autophosphorylation in response to DNA d...
(hasEvent)	[Pathway:6804756] Regulation of TP53 Activity through Phosphorylation [Homo sapiens]
(precedingEvent)	[Reaction:6798615] TP53 binds the TP53AIP1 gene [Homo sapiens]
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No pathways have been reviewed or authored by HIPK2 phosphorylates TP53 (6799409)